Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells. - Wikidata - wikimedia - TriplyDB

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

http://www.wikidata.org/entity/Q37201960

about

Evolved tumor suppression: why are we so good at not getting cancer?Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells.The HOXB4 homeoprotein promotes the ex vivo enrichment of functional human embryonic stem cell-derived NK cells Hematopoietic RIPK1 deficiency results in bone marrow failure caused by apoptosis and RIPK3-mediated necroptosis.Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.Overcoming reprogramming resistance of Fanconi anemia cells.Extracellular matrix protein Matrilin-4 regulates stress-induced HSC proliferation via CXCR4 Leukemic survival factor SALL4 contributes to defective DNA damage repair.TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis.Increased HoxB4 Inhibits Apoptotic Cell Death in Pro-B Cells.Genetic correction of hematopoiesis in Fanconi anemia: the case for a non-HSC-autonomous defect.HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4 The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors Ex vivoexpansion of cord blood-CD34+cells using IGFBP2and Angptl-5 impairs short-term lymphoid repopulationin vivo

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Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-{alpha} on Fanconi anemia hematopoietic stem and progenitor cells.

http://www.wikidata.org/entity/Q37201960

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on 06 March 2009

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vedecký článok

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vetenskaplig artikel

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Ectopic HOXB4 overcomes the in ...... tic stem and progenitor cells.

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BLOOD-2008-09-180224

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Ectopic HOXB4 overcomes the in ...... tic stem and progenitor cells.

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Bernhard Schiedlmeier

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Christopher Baum

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Dandan Li

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David A Williams

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Jeff Bailey

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Leslie J Fairbairn

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Mi-Ok Kim

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Michael D Milsom

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Michael Jansen

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Michelle Kirby

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P2860

FANCC interacts with Hsp70 to protect hematopoietic cells from IFN-gamma/TNF-alpha-mediated cytotoxicity.

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

Differential effects of HOXB4 on nonhuman primate short- and long-term repopulating cells

Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation

The Fanconi anemia complementation group C gene product: structural evidence of multifunctionality

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

Induction by alkylating agents of sister chromatid exchanges and chromatid breaks in Fanconi's anemia

Inhibitory effects of tumor necrosis factor on hematopoiesis seen in vitro are translated to increased numbers of both committed and multipotent progenitors in TNF-deficient mice.

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5111-5120

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10.1182/BLOOD-2008-09-180224

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Abdullah M. Ali

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2009-03-06T00:00:00Z

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