The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

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DRAM Is Involved in Regulating Nucleoside Analog-Induced Neuronal Autophagy in a p53-Independent Manner.Off-Target Effects of Drugs that Disrupt Human Mitochondrial DNA Maintenance.

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Q40305534-010A0C70-5EC3-4269-85DD-3A1AB9884D85 Q47125109-49E9B2A5-6D27-401C-8F72-D1A0B4D65C40

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The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on 05 July 2016

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The DNA Polymerase Gamma R953C ...... Induced Mitochondrial Toxicity

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The DNA Polymerase Gamma R953C ...... nduced Mitochondrial Toxicity.

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The DNA Polymerase Gamma R953C ...... Induced Mitochondrial Toxicity

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The DNA Polymerase Gamma R953C ...... nduced Mitochondrial Toxicity.

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The DNA Polymerase Gamma R953C ...... Induced Mitochondrial Toxicity

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The DNA Polymerase Gamma R953C ...... nduced Mitochondrial Toxicity.

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The DNA Polymerase Gamma R953C ...... Induced Mitochondrial Toxicity

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Andrea C Mislak

http://www.w3.org/2001/XMLSchema#string

Christie K Shumate

http://www.w3.org/2001/XMLSchema#string

Elijah Paintsil

http://www.w3.org/2001/XMLSchema#string

Esinam Agbosu

http://www.w3.org/2001/XMLSchema#string

Karen S Anderson

http://www.w3.org/2001/XMLSchema#string

Min Li

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Shreya Bhandari

http://www.w3.org/2001/XMLSchema#string

Vivek Bose

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Y Whitney Yin

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Yram Foli

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Antiretroviral therapy-induced mitochondrial toxicity: potential mechanisms beyond polymerase-γ inhibition.

Pharmacology of nucleoside and nucleotide reverse transcriptase inhibitor-induced mitochondrial toxicity.

Clinical manifestations and management of antiretroviral nucleoside analog-related mitochondrial toxicity.

DNA polymerase gamma, the mitochondrial replicase.

Antiretroviral therapy-induced toxicity is associated with increased mRNA expression of telomerase.

Consequences of mutations in human DNA polymerase gamma.

Mutations in human DNA polymerase γ confer unique mechanisms of catalytic deficiency that mirror the disease severity in mitochondrial disorder patients.

R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity

Increased mtDNA levels without change in mitochondrial enzymes in peripheral blood mononuclear cells of infants born to HIV-infected mothers on antiretroviral therapy

Structural determinants in human DNA polymerase gamma account for mitochondrial toxicity from nucleoside analogs.

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5608-5611

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scholarly article

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10.1128/AAC.00976-16

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English

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http://www.w3.org/2001/XMLSchema#string

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http://www.w3.org/2001/XMLSchema#string

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Michal R Szymanski

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2016-07-05T00:00:00Z

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27381400

http://www.w3.org/2001/XMLSchema#string

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antiretroviral drug

P932

4997837

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The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

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The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity

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P2093

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P356

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P698

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