Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2
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The altered renal and hepatic expression of solute carrier transporters (SLCs) in type 1 diabetic micePDZK1 and NHERF1 regulate the function of human organic anion transporting polypeptide 1A2 (OATP1A2) by modulating its subcellular trafficking and stability.Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cellsHuman oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins.The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters.Trafficking and other regulatory mechanisms for organic anion transporting polypeptides and organic anion transporters that modulate cellular drug and xenobiotic influx and that are dysregulated in disease.High-throughput pharmacogenetics identifies SLCO1A2 polymorphisms as candidates to elucidate the risk of febrile neutropenia in the breast cancer RAPP-01 trial.Interaction of the bioactive flavonol, icariin, with the essential human solute carrier transporters.
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Functional analysis of novel polymorphisms in the human SLCO1A2 gene that encodes the transporter OATP1A2
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 06 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Functional analysis of novel p ...... ncodes the transporter OATP1A2
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Functional analysis of novel p ...... codes the transporter OATP1A2.
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type
label
Functional analysis of novel p ...... ncodes the transporter OATP1A2
@en
Functional analysis of novel p ...... codes the transporter OATP1A2.
@nl
prefLabel
Functional analysis of novel p ...... ncodes the transporter OATP1A2
@en
Functional analysis of novel p ...... codes the transporter OATP1A2.
@nl
P2093
P2860
P50
P1433
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Functional analysis of novel p ...... ncodes the transporter OATP1A2
@en
P2093
Andreas Jodal
Jian Zheng
Michael Murray
P2860
P2888
P304
P356
10.1208/S12248-013-9515-1
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P577
2013-08-06T00:00:00Z
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P6179
1034625375