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beta-Secretase as a therapeutic target for Alzheimer's disease.

beta-Secretase as a therapeutic target for Alzheimer's disease.

http://www.wikidata.org/entity/Q37215845

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Recent developments in Alzheimer's disease therapeutics Diverse molecular targets for therapeutic strategies in Alzheimer's disease Alzheimer's therapeutics: translation of preclinical science to clinical drug development Computational Insights into Substrate and Site Specificities, Catalytic Mechanism, and Protonation States of the Catalytic Asp Dyad of β -Secretase Targeting mRNA for Alzheimer's and related dementias.Development and Structural Modification of BACE1 Inhibitors Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms Application of consensus scoring and principal component analysis for virtual screening against β-secretase (BACE-1)FLZ alleviates the memory deficits in transgenic mouse model of Alzheimer's disease via decreasing beta-amyloid production and tau hyperphosphorylation Pepsin homologues in bacteria Integrating experimentation and quantitative modeling to enhance discovery of Beta amyloid lowering therapeutics for Alzheimer's disease.Beta-secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice.Enhanced red-emitting railroad worm luciferase for bioassays and bioimaging Predicting memapsin 2 (β-secretase) hydrolytic activity.Phospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD mice Alzheimer's disease biomarker discovery in symptomatic and asymptomatic patients: experimental approaches and future clinical applications.Targeting Abeta and tau in Alzheimer's disease, an early interim report Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.BACE1 inhibitory activity of fungal endophytic extracts from Malaysian medicinal plants AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).Comparison of pharmacological modulation of APP metabolism in primary chicken telencephalic neurons and in a human neuroglioma cell line Targets for AD treatment: conflicting messages from γ-secretase inhibitors High glucose promotes Aβ production by inhibiting APP degradation.Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand.Novel in vitro inhibitory functions of potato tuber proteinaceous inhibitors Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer's disease Drosophila models.In Silico Design of Beta-Secretase Inhibitors in Alzheimer's Disease.Developing β-secretase inhibitors for treatment of Alzheimer's disease.Cutting in on a secretase pas de deux An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.Exploring novel mechanistic insights in Alzheimer's disease by assessing reliability of protein interactions.The Components of Flemingia macrophylla Attenuate Amyloid β-Protein Accumulation by Regulating Amyloid β-Protein Metabolic Pathway.Identification of novel acetylcholinesterase inhibitors through e-pharmacophore-based virtual screening and molecular dynamics simulations.Effects and possible mechanisms of action of acacetin on the behavior and eye morphology of Drosophila models of Alzheimer's disease.Regulation of cerebral cholesterol metabolism in Alzheimer disease.Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma.A large and accurate collection of peptidase cleavages in the MEROPS database.Novel strategies for the prevention of dementia from Alzheimer's disease.

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beta-Secretase as a therapeutic target for Alzheimer's disease.

http://www.wikidata.org/entity/Q37215845

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

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scientific article published on July 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

beta-Secretase as a therapeutic target for Alzheimer's disease.

@en

beta-Secretase as a therapeutic target for Alzheimer's disease.

@nl

type

label

beta-Secretase as a therapeutic target for Alzheimer's disease.

@en

beta-Secretase as a therapeutic target for Alzheimer's disease.

@nl

prefLabel

beta-Secretase as a therapeutic target for Alzheimer's disease.

@en

beta-Secretase as a therapeutic target for Alzheimer's disease.

@nl

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J.NURT.2008.05.007

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Neurotherapeutics

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beta-Secretase as a therapeutic target for Alzheimer's disease.

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Arun K Ghosh

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Jordan Tang

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Sandra Gemma

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P2860

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

Purification and cloning of amyloid precursor protein beta-secretase from human brain

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

Crystal structure of memapsin 2 (beta-secretase) in complex with an inhibitor OM00-3

Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind beta-secretase in a N-terminal 10s-loop down conformation

Design, synthesis, and crystal structure of hydroxyethyl secondary amine-based peptidomimetic inhibitors of human beta-secretase

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j.nurt.2008.05.007

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399-408

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scholarly article

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10.1016/J.NURT.2008.05.007

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3

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1010986901

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18625451

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Alzheimer's disease

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2963069

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