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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

http://www.wikidata.org/entity/Q37217491

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Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown Low Serum Angiopoietin-1, High Serum Angiopoietin-2, and High Ang-2/Ang-1 Protein Ratio are Associated with Early Onset Sepsis in Surinamese Newborns.Tie1 controls angiopoietin function in vascular remodeling and inflammation.Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization.Dimerization of Tie2 mediated by its membrane-proximal FNIII domains.Plastic roles of pericytes in the blood-retinal barrier.Pericyte-expressed Tie2 controls angiogenesis and vessel maturation.The Angiopoietin-Tie2 Signaling Axis in Systemic Inflammation.Tie1: an orphan receptor provides context for angiopoietin-2/Tie2 signaling.Therapeutic targeting of the angiopoietin-TIE pathway.Angiopoietins and Tie2 in vascular inflammation.YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.Overview of small bowel angioectasias: clinical presentation and treatment options.Strategies for preventing peritoneal fibrosis in peritoneal dialysis patients: new insights based on peritoneal inflammation and angiogenesis.Pharmacologic management of diabetic retinopathy.Endothelial Tie1-mediated angiogenesis and vascular abnormalization promote tumor progression and metastasis.Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.Cyp2c44 gene disruption is associated with increased hematopoietic stem cells: implication in chronic hypoxia-induced pulmonary hypertension.Tie2 protects the vasculature against thrombus formation in systemic inflammation.Endothelial Activation: The Ang/Tie Axis in Sepsis.Pathophysiology of Diabetic Retinopathy: The Old and the New

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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

http://www.wikidata.org/entity/Q37217491

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 22 August 2016

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

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name

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

@en

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

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type

label

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

@en

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

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prefLabel

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

@en

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation.

@nl

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Journal of Clinical Investigation

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Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation

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Christopher Daly

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Donald M McDonald

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Emilia A Korhonen

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Gavin Thurston

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Maximilian Nitschké

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Minah Kim

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Peter Baluk

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Pipsa Saharinen

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P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding

Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts

Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1

Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans

Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects

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3511-3525

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scholarly article

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10.1172/JCI84871

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9

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126

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2016-08-22T00:00:00Z

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27548529

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5004955

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