Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia - Wikidata - wikimedia - TriplyDB

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

http://www.wikidata.org/entity/Q37219413

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KATNAL1 regulation of sertoli cell microtubule dynamics is essential for spermiogenesis and male fertility Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion Quantitative measurements and modeling of cargo-motor interactions during fast transport in the living axon.Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia Microtubule-severing enzymes at the cutting edge Hereditary spastic paraplegia SPG4: what is known and not known about the disease.Spg20-/- mice reveal multimodal functions for Troyer syndrome protein spartin in lipid droplet maintenance, cytokinesis and BMP signaling Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules.Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transport.Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.Spastin, atlastin, and ER relocalization are involved in axon but not dendrite regeneration.A cryptic promoter in the first exon of the SPG4 gene directs the synthesis of the 60-kDa spastin isoform.Pharmacologic rescue of axon growth defects in a human iPSC model of hereditary spastic paraplegia SPG3A.Connecting the cytoskeleton to the endoplasmic reticulum and Golgi.Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.Strategies for diminishing katanin-based loss of microtubules in tauopathic neurodegenerative diseases.Spastin binds to lipid droplets and affects lipid metabolism.Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation Models, Regulations, and Functions of Microtubule Severing by Katanin Beyond taxol: microtubule-based treatment of disease and injury of the nervous system.Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics.Axonal transport defects in neurodegenerative diseases.Loss of spastin function results in disease-specific axonal defects in human pluripotent stem cell-based models of hereditary spastic paraplegia.Gene dosage-dependent rescue of HSP neurite defects in SPG4 patients' neurons.Cellular pathways of hereditary spastic paraplegia.Modeling Axonal Defects in Hereditary Spastic Paraplegia with Human Pluripotent Stem Cells.Invited review: Microtubule severing enzymes couple atpase activity with tubulin GTPase spring loading.Regulation of motor proteins, axonal transport deficits and adult-onset neurodegenerative diseases.Contribution of the Degeneration of the Neuro-Axonal Unit to the Pathogenesis of Multiple Sclerosis.Truncating mutations of SPAST associated with hereditary spastic paraplegia indicate greater accumulation and toxicity of the M1 isoform of spastin.Acetylation of microtubules influences their sensitivity to severing by katanin in neurons and fibroblasts Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia.A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis.It cuts two ways: microtubule loss during Alzheimer disease.Targeted disruption of the Mast syndrome gene SPG21 in mice impairs hind limb function and alters axon branching in cultured cortical neurons.Reep1 null mice reveal a converging role for hereditary spastic paraplegia proteins in lipid droplet regulation.Mutant spastin proteins promote deficits in axonal transport through an isoform-specific mechanism involving casein kinase 2 activation.SPAST mutations in Australian patients with hereditary spastic paraplegia.

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Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

http://www.wikidata.org/entity/Q37219413

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on February 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Quantitative and functional an ...... hereditary spastic paraplegia

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Quantitative and functional an ...... hereditary spastic paraplegia.

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type

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Quantitative and functional an ...... hereditary spastic paraplegia

@en

Quantitative and functional an ...... hereditary spastic paraplegia.

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prefLabel

Quantitative and functional an ...... hereditary spastic paraplegia

@en

Quantitative and functional an ...... hereditary spastic paraplegia.

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JNEUROSCI.3159-07.2008

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Journal of Neuroscience

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Quantitative and functional an ...... hereditary spastic paraplegia

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Aditi Falnikar

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B Timothy Himes

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Dongyang Huang

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Gerardo Morfini

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Joanna M Solowska

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Peter W Baas

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Scott T Brady

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P2860

Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit

Regulation of microtubule severing by katanin subunits during neuronal development.

Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia.

A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)

An essential role for katanin in severing microtubules in the neuron

Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia

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2147-2157

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scholarly article

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10.1523/JNEUROSCI.3159-07.2008

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28

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5547718

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18305248

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2693295

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