Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model
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Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatmentCurcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cellsThe nontoxic natural compound Curcumin exerts anti-proliferative, anti-migratory, and anti-invasive properties against malignant gliomas.Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy.The multifaceted role of curcumin in cancer prevention and treatment.Phytochemicals in cancer prevention and therapy: truth or dare?Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy.Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activityCelastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.Curcumin and its analogue induce apoptosis in leukemia cells and have additive effects with bortezomib in cellular and xenograft modelsSensitizing human multiple myeloma cells to the proteasome inhibitor bortezomib by novel curcumin analogs.Curcumin enhances cytotoxic effects of bortezomib in human multiple myeloma H929 cells: potential roles of NF-κB/JNKTargeting tumor ubiquitin-proteasome pathway with polyphenols for chemosensitization.Effects of curcumin in pediatric epithelial liver tumors: inhibition of tumor growth and alpha-fetoprotein in vitro and in vivo involving the NFkappaB- and the beta-catenin pathways.Fluorocurcumins as cyclooxygenase-2 inhibitor: molecular docking, pharmacokinetics and tissue distribution in miceNanoparticle delivery of natural products in the prevention and treatment of cancers: current status and future prospects.Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics.Triptolide avoids cisplatin resistance and induces apoptosis via the reactive oxygen species/nuclear factor-κB pathway in SKOV3(PT) platinum-resistant human ovarian cancer cells.Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse modelCurcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs.Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part I.Using NF-κB as a molecular target for theranostics in radiation oncology research.Curcumin in various cancers.The role of epigenetics in the biology of multiple myeloma.Hybrid curcumin compounds: a new strategy for cancer treatment.Matrine and CYC116 synergistically inhibit growth and induce apoptosis in multiple myeloma cells.A preliminary study of the effect of curcumin on the expression of p53 protein in a human multiple myeloma cell line.Curcumin induces cell death of the main molecular myeloma subtypes, particularly the poor prognosis subgroups.FTIR spectroscopy reveals lipid droplets in drug resistant laryngeal carcinoma cells through detection of increased ester vibrational bands intensity.Anticancer Activity of Curcumin and Its Analogues: Preclinical and Clinical Studies.Design and biological characterization of hybrid compounds of curcumin and thalidomide for multiple myeloma.Curcumin inhibits prostate cancer metastasis in vivo by targeting the inflammatory cytokines CXCL1 and -2.Norcantharidin enhances bortezomib-antimyeloma activity in multiple myeloma cells in vitro and in nude mouse xenografts.Long-term stabilisation of myeloma with curcumin.Phyto-polyphenols as potential inhibitors of breast cancer metastasis.
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P2860
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on April 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Curcumin circumvents chemoresi ...... ple myeloma in nude mice model
@en
Curcumin circumvents chemoresi ...... le myeloma in nude mice model.
@nl
type
label
Curcumin circumvents chemoresi ...... ple myeloma in nude mice model
@en
Curcumin circumvents chemoresi ...... le myeloma in nude mice model.
@nl
prefLabel
Curcumin circumvents chemoresi ...... ple myeloma in nude mice model
@en
Curcumin circumvents chemoresi ...... le myeloma in nude mice model.
@nl
P2093
P2860
P1476
Curcumin circumvents chemoresi ...... ple myeloma in nude mice model
@en
P2093
Ajaikumar B Kunnumakkara
Bharat B Aggarwal
Bokyung Sung
Preetha Anand
Sushovan Guha
P2860
P304
P356
10.1158/1535-7163.MCT-08-0905
P50
P577
2009-04-01T00:00:00Z