2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides
about
Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic interventionAssessing phospholipase A2 activity toward cardiolipin by mass spectrometryPotent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.Inhibition of secreted phospholipases A₂ by 2-oxoamides based on α-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.Calcium-independent phospholipases A2 and their roles in biological processes and diseases.Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.Phospholipase A2 inhibitors as potential therapeutic agents for the treatment of inflammatory diseases.Protective effect of cytosolic phospholipase A2 inhibition against inflammation and degeneration by promoting regulatory T cells in rats with experimental autoimmune encephalomyelitis.Computer-aided drug design guided by hydrogen/deuterium exchange mass spectrometry: A powerful combination for the development of potent and selective inhibitors of Group VIA calcium-independent phospholipase A2.2-Oxoamide inhibitors of cytosolic group IVA phospholipase A2 with reduced lipophilicity.Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics.Off-target effect of the cPLA2α inhibitor pyrrophenone: Inhibition of calcium release from the endoplasmic reticulum2-Oxoamides based on dipeptides as selective calcium-independent phospholipase A2 inhibitors.Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2.
P2860
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P2860
2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 03 May 2009
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
2-Oxoamide inhibitors of phosp ...... ipeptides and pseudodipeptides
@en
2-Oxoamide inhibitors of phosp ...... peptides and pseudodipeptides.
@nl
type
label
2-Oxoamide inhibitors of phosp ...... ipeptides and pseudodipeptides
@en
2-Oxoamide inhibitors of phosp ...... peptides and pseudodipeptides.
@nl
prefLabel
2-Oxoamide inhibitors of phosp ...... ipeptides and pseudodipeptides
@en
2-Oxoamide inhibitors of phosp ...... peptides and pseudodipeptides.
@nl
P2093
P2860
P1476
2-Oxoamide inhibitors of phosp ...... ipeptides and pseudodipeptides
@en
P2093
Andrej Grkovich
Daren Stephens
Dimitrios Kalogiannidis
Efrosini Barbayianni
George Kokotos
Panagiotis Dolatzas
Yuan-Hao Hsu
P2860
P304
P356
10.1016/J.BMC.2009.03.069
P407
P577
2009-05-03T00:00:00Z