The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas.
about
A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer.Phase I study of oral rigosertib (ON 01910.Na), a dual inhibitor of the PI3K and Plk1 pathways, in adult patients with advanced solid malignanciesDNA Damage Response Proteins and Oxygen Modulate Prostaglandin E2 Growth Factor Release in Response to Low and High LET Ionizing Radiation.Cell cycle proteins as promising targets in cancer therapyDysregulations in the PI3K pathway and targeted therapies for head and neck squamous cell carcinomaBarriers to generating PDX models of HPV-related head and neck cancer.ON 01910.Na (rigosertib) inhibits PI3K/Akt pathway and activates oxidative stress signals in head and neck cancer cell lines.Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.
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The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
@en
The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
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type
label
The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
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The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
@nl
prefLabel
The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
@en
The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
@nl
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The dual pathway inhibitor rig ...... neck squamous cell carcinomas.
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Adrian Umpierrez
Aik-Choon Tan
Antonio Jimeno
Barbara A Frederick
Brian W Vogler
Daniel Sehrt
Daniel W Bowles
Dara L Aisner
David P Astling
Francois Wilhelm
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P304
P356
10.1158/1535-7163.MCT-13-0206
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2013-07-19T00:00:00Z