Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria.
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Flexible heteroarotinoid (Flex-Het) SHetA2 inhibits angiogenesis in vitro and in vivoProtein interacting with C kinase 1 suppresses invasion and anchorage-independent growth of astrocytic tumor cellsDevelopment of flexible-heteroarotinoids for kidney cancerNF-kappaB is involved in SHetA2 circumvention of TNF-alpha resistance, but not induction of intrinsic apoptosis.Synthesis and cytotoxicity studies of novel triazolo-benzoxazepine as new anticancer agents.Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.Single-cell analysis reveals early manifestation of cancerous phenotype in pre-malignant esophageal cells.Anticancer/antiviral agent Akt inhibitor-IV massively accumulates in mitochondria and potently disrupts cellular bioenergetics.Chaetoglobosin K induces apoptosis and G2 cell cycle arrest through p53-dependent pathway in cisplatin-resistant ovarian cancer cellsLZ-207, a Newly Synthesized Flavonoid, Induces Apoptosis and Suppresses Inflammation-Related Colon Cancer by Inhibiting the NF-κB Signaling Pathway.Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation.Synthesis and cytotoxicity studies of 1-propenyl-1,3-dihydro-benzimidazol-2-one.Myricetin inhibits proliferation of cisplatin-resistant cancer cells through a p53-dependent apoptotic pathway.Comparison of cytotoxicity between extracts of Clinacanthus nutans (Burm. f.) Lindau leaves from different locations and the induction of apoptosis by the crude methanol leaf extract in D24 human melanoma cells.Theaflavin-3, 3'-digallate induces apoptosis and G2 cell cycle arrest through the Akt/MDM2/p53 pathway in cisplatin-resistant ovarian cancer A2780/CP70 cells.Chemoprevention of colon and small intestinal tumorigenesis in APC(min/+) mice by SHetA2 (NSC721689) without toxicity.Heteroarotinoids with anti-cancer activity against ovarian cancer cellsGene expression analysis of biological systems driving an organotypic model of endometrial carcinogenesis and chemoprevention.Induction of death receptor ligand-mediated apoptosis in epithelial ovarian carcinoma: The search for sensitizing agents.ATM-dependent phosphorylation of MEF2D promotes neuronal survival after DNA damage.Targeting malignant mitochondria with therapeutic peptides.Examining impacts of ceranib-2 on the proliferation, morphology and ultrastructure of human breast cancer cells.FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells.Celastrol induces apoptosis in gefitinib-resistant non-small cell lung cancer cells via caspases-dependent pathways and Hsp90 client protein degradation.SHetA2 interference with mortalin binding to p66shc and p53 identified using drug-conjugated magnetic microspheresOral toxicity and pharmacokinetic studies of SHetA2, a new chemopreventive agent, in rats and dogs.IR- Role of adaptor protein p66Shc in renal pathologies.Development of a dietary formulation of the SHetA2 chemoprevention drug for mice.A fluorescent guanosine dinucleoside as a selective switch-on sensor for c-myc G-quadruplex DNA with potent anticancer activities.Pharmacokinetics and interspecies scaling of a novel, orally-bioavailable anti-cancer drug, SHetA2.
P2860
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P2860
Flex-Hets differentially induce apoptosis in cancer over normal cells by directly targeting mitochondria.
description
article científic
@ca
article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on June 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@en
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@nl
type
label
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@en
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@nl
prefLabel
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@en
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@nl
P2093
P2860
P1476
Flex-Hets differentially induc ...... rectly targeting mitochondria.
@en
P2093
Bethany Hannafon
Doris Benbrook
Lance Gill
Tongzu Liu
William Kelly
P2860
P304
P356
10.1158/1535-7163.MCT-06-0279
P577
2007-06-01T00:00:00Z