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Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

http://www.wikidata.org/entity/Q37239616

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The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals Cytogenomics of hexavalent chromium (Cr 6+) exposed cells: a comprehensive review Advances in Understanding How Heavy Metal Pollution Triggers Gastric Cancer Developmental neurotoxicants in e-waste: an emerging health concern Chromium genotoxicity: A double-edged sword Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity Alzheimer's disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans Environmental chemical exposures and human epigenetics Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium Application of the U.S. EPA mode of action Framework for purposes of guiding future research: a case study involving the oral carcinogenicity of hexavalent chromium Epigenetics in metal carcinogenesis: nickel, arsenic, chromium and cadmium.Comparison of gene expression profiles in chromate transformed BEAS-2B cells Involvement of p53 mutation and mismatch repair proteins dysregulation in NNK-induced malignant transformation of human bronchial epithelial cells Epigenetics across the human lifespan.Role of DNA methylation in cell cycle arrest induced by Cr (VI) in two cell lines.The redox basis of epigenetic modifications: from mechanisms to functional consequences.Chromium in drinking water: sources, metabolism, and cancer risks Inhalable metal-rich air particles and histone H3K4 dimethylation and H3K9 acetylation in a cross-sectional study of steel workers.Environmental epigenetics in metal exposure.Comparison of the effects of hexavalent chromium in the alimentary canal of F344 rats and B6C3F1 mice following exposure in drinking water: implications for carcinogenic modes of action.Epigenetic Contributions to the Relationship between Cancer and Dietary Intake of Nutrients, Bioactive Food Components, and Environmental Toxicants.Histone Methylation in Nickel-Smelting Industrial Workers Oral Chromium Exposure and Toxicity.Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.Undetectable role of oxidative DNA damage in cell cycle, cytotoxic and clastogenic effects of Cr(VI) in human lung cells with restored ascorbate levels.Vitamin and antioxidant rich diet increases MLH1 promoter DNA methylation in DMT2 subjects.Towards incorporating epigenetic mechanisms into carcinogen identification and evaluation.Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-κB.Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment.Epigenetic mechanisms in metal toxicity.Effects of environmental stressors on histone modifications and their relevance to carcinogenesis: a systematic review.Impact of hexavalent chromium on mammalian cell bioenergetics: phenotypic changes, molecular basis and potential relevance to chromate-induced lung cancer.Traffic-derived particulate matter exposure and histone H3 modification: A repeated measures study.Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells.Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1.Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9.Upregulation of histone-lysine methyltransferases plays a causal role in hexavalent chromium-induced cancer stem cell-like property and cell transformation.Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure.

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Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

http://www.wikidata.org/entity/Q37239616

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 17 April 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

@en

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.

@nl

type

label

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

@en

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.

@nl

prefLabel

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

@en

Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium.

@nl

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J.TAAP.2009.04.008

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Toxicology and Applied Pharmacology

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Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

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Haobin Chen

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Hong Sun

http://www.w3.org/2001/XMLSchema#string

Max Costa

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Qin Li

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Xue Zhou

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P2860

Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island

Gene expression profile in response to chromium-induced cell stress in A549 cells.

JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor

DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Direct interaction between DNMT1 and G9a coordinates DNA and histone methylation during replication

Chromate-induced epimutations in mammalian cells

The language of covalent histone modifications

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics

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258-266

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10.1016/J.TAAP.2009.04.008

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3

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hexavalent chromium

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