Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial
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Adaptive designs undertaken in clinical research: a review of registered clinical trialsBiomarker-Guided Adaptive Trial Designs in Phase II and Phase III: A Methodological ReviewCelecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial.Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials.Failure-Free Survival and Radiotherapy in Patients With Newly Diagnosed Nonmetastatic Prostate Cancer: Data From Patients in the Control Arm of the STAMPEDE Trial.Measuring the impact of methodological research: a framework and methods to identify evidence of impactA multi-arm multi-stage clinical trial design for binary outcomes with application to tuberculosisAdaptive clinical trial designs in oncology.The STAMPEDE trial: paradigm-changing data through innovative trial design.Clinical trial designs for rare diseases: studies developed and discussed by the International Rare Cancers InitiativeFlexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial.A modest proposal for dropping poor arms in clinical trials.Addition of docetaxel, zoledronic acid, or both to first-line long-term hormone therapy in prostate cancer (STAMPEDE): survival results from an adaptive, multiarm, multistage, platform randomised controlled trial.Some recommendations for multi-arm multi-stage trialsPlanning multi-arm screening studies within the context of a drug development program.Preventing recurrence of endometriosis by means of long-acting progestogen therapy (PRE-EMPT): report of an internal pilot, multi-arm, randomised controlled trial incorporating flexible entry design and adaption of design based on feasibility of recBone metastasis in prostate cancer: emerging therapeutic strategies.Integrated phase II/III clinical trials in oncology: a case study.A review and re-interpretation of a group-sequential approach to sample size re-estimation in two-stage trials.Adding Celecoxib With or Without Zoledronic Acid for Hormone-Naïve Prostate Cancer: Long-Term Survival Results From an Adaptive, Multiarm, Multistage, Platform, Randomized Controlled Trial.Multi-armed Bandit Models for the Optimal Design of Clinical Trials: Benefits and ChallengesDevelopment of a Bayesian response-adaptive trial design for the Dexamethasone for Excessive Menstruation study.A comparison of Bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials.Controlling the family-wise error rate in multi-arm, multi-stage trials.Type I error rates of multi-arm multi-stage clinical trials: strong control and impact of intermediate outcomes.A multi-stage drop-the-losers design for multi-arm clinical trials.Reply to Dodd and Proschan.Two-by-Two Factorial Cancer Treatment Trials: Is Sufficient Attention Being Paid to Possible Interactions?Design and monitoring of multi-arm multi-stage clinical trials.Comments on 'A modest proposal for dropping poor arms in clinical trials' by Proschan and Dodd.Accurate p-values for adaptive designs with binary endpoints.Incorporating Biomarker Stratification into STAMPEDE: an Adaptive Multi-arm, Multi-stage Trial Platform.Testing many treatments within a single protocol over 10 years at MRC Clinical Trials Unit at UCL: Multi-arm, multi-stage platform, umbrella and basket protocols.Interval estimation in multi-stage drop-the-losers designs.Adding abiraterone or docetaxel to long-term hormone therapy for prostate cancer: directly randomised data from the STAMPEDE multi-arm, multi-stage platform protocol.Adaptive designs in clinical trials: why use them, and how to run and report them.What is the optimal systemic treatment of men with metastatic, hormone-naive prostate cancer? A STOPCAP systematic review and network meta-analysis.Reflections on attempted Anglo-Japanese collaboration on STAMPEDE: A randomized controlled trial for men with prostate cancer
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Issues in applying multi-arm multi-stage methodology to a clinical trial in prostate cancer: the MRC STAMPEDE trial
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Issues in applying multi-arm m ...... cancer: the MRC STAMPEDE trial
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Issues in applying multi-arm m ...... ancer: the MRC STAMPEDE trial.
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type
label
Issues in applying multi-arm m ...... cancer: the MRC STAMPEDE trial
@en
Issues in applying multi-arm m ...... ancer: the MRC STAMPEDE trial.
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prefLabel
Issues in applying multi-arm m ...... cancer: the MRC STAMPEDE trial
@en
Issues in applying multi-arm m ...... ancer: the MRC STAMPEDE trial.
@nl
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Issues in applying multi-arm m ...... cancer: the MRC STAMPEDE trial
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David P Dearnaley
Karen Sanders
Mahesh K B Parmar
Malcolm D Mason
Nicholas D James
Rachel C Morgan
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P2888
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10.1186/1745-6215-10-39
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2009-06-11T00:00:00Z
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P6179
1005761057