Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.
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Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion.A Novel Closed-Head Model of Mild Traumatic Brain Injury Using Focal Primary Overpressure Blast to the Cranium in Mice.Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsDifferential loss of thalamostriatal and corticostriatal input to striatal projection neuron types prior to overt motor symptoms in the Q140 knock-in mouse model of Huntington's disease.Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's diseaseDifferential organization of cortical inputs to striatal projection neurons of the matrix compartment in rats.Use of a force-sensing automated open field apparatus in a longitudinal study of multiple behavioral deficits in CAG140 Huntington's disease model miceSelective expression of mutant huntingtin during development recapitulates characteristic features of Huntington's diseaseCholinergic Interneurons Amplify Corticostriatal Synaptic Responses in the Q175 Model of Huntington's Disease.Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.Corticostriatal synaptic adaptations in Huntington's diseaseThe Complexity of Clinical Huntington's Disease: Developments in Molecular Genetics, Neuropathology and Neuroimaging Biomarkers.Unravelling and Exploiting Astrocyte Dysfunction in Huntington's Disease.Induced Pluripotent Stem Cells in Huntington's Disease Research: Progress and Opportunity.Quinazoline-based tricyclic compounds that regulate programmed cell death, induce neuronal differentiation, and are curative in animal models for excitotoxicity and hereditary brain diseaseDysregulation of Corticostriatal Connectivity in Huntington's Disease: A Role for Dopamine ModulationCholinergic interneurons in the Q140 knockin mouse model of Huntington's disease: Reductions in dendritic branching and thalamostriatal input.Differential electrophysiological and morphological alterations of thalamostriatal and corticostriatal projections in the R6/2 mouse model of Huntington's disease.TSPO as a target for treatments of diseases, including neuropathological disorders.Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington's disease.Altered PDE10A expression detectable early before symptomatic onset in Huntington's disease.Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.Molecular insights into cortico-striatal miscommunications in Huntington's disease.Transcriptional regulatory networks underlying gene expression changes in Huntington's disease.Disrupted striatal neuron inputs and outputs in Huntington's disease.
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Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 August 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Loss of corticostriatal and th ...... 140 Huntington's disease mice.
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Loss of corticostriatal and th ...... 140 Huntington's disease mice.
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type
label
Loss of corticostriatal and th ...... 140 Huntington's disease mice.
@en
Loss of corticostriatal and th ...... 140 Huntington's disease mice.
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prefLabel
Loss of corticostriatal and th ...... 140 Huntington's disease mice.
@en
Loss of corticostriatal and th ...... 140 Huntington's disease mice.
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P2093
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Loss of corticostriatal and th ...... 140 Huntington's disease mice.
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P2093
P2860
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10.1016/J.NBD.2013.08.009
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2013-08-19T00:00:00Z