Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. - Wikidata - wikimedia - TriplyDB

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

http://www.wikidata.org/entity/Q37257222

about

PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers Targeting the Pim kinases in multiple myeloma Class III β-tubulin and the cytoskeletal gateway for drug resistance in ovarian cancer The PIM kinases in hematological cancers PIM1 kinase as a target for cancer therapy Fragment-hopping-based discovery of a novel chemical series of proto-oncogene PIM-1 kinase inhibitors Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia The role of PIM1/PIM2 kinases in tumors of the male reproductive system The oncogenic kinase Pim-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells.PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer Pim1 kinase is required to maintain tumorigenicity in MYC-expressing prostate cancer cells.Computational prediction and experimental validation of a novel synthesized pan-PIM inhibitor PI003 and its apoptosis-inducing mechanisms in cervical cancer.Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.PIM1 regulates glycolysis and promotes tumor progression in hepatocellular carcinoma PIM kinases are progression markers and emerging therapeutic targets in diffuse large B-cell lymphoma.Control of Pim2 kinase stability and expression in transformed human haematopoietic cells Functional role and therapeutic potential of the pim-1 kinase in colon carcinoma.Low tristetraprolin expression promotes cell proliferation and predicts poor patients outcome in pancreatic cancer.PIM kinases as therapeutic targets against advanced melanoma.Inflammation and survival pathways: chronic lymphocytic leukemia as a model system.Why target PIM1 for cancer diagnosis and treatment?Pim-1 kinase inhibits pathological injury by promoting cardioprotective signaling.The PIM family of serine/threonine kinases in cancer.PIM kinases: an overview in tumors and recent advances in pancreatic cancer.PIM kinase (and Akt) biology and signaling in tumors.PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.Hypoxia-responsive miR-124 and miR-144 reduce hypoxia-induced autophagy and enhance radiosensitivity of prostate cancer cells via suppressing PIM1.Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine.Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines.Pim-1 plays a pivotal role in hypoxia-induced chemoresistance.PIM-1 mRNA expression is a potential prognostic biomarker in acute myeloid leukemia.Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus.Inhibition of tumour angiogenesis and growth by small hairpin HIF-1α and IL-8 in hepatocellular carcinoma.Decreased levels of circulating and tissue miR-107 in human esophageal cancer.Hispidulin suppresses cell growth and metastasis by targeting PIM1 through JAK2/STAT3 signaling in colorectal cancer.

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P2860

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

http://www.wikidata.org/entity/Q37257222

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 15 June 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@en

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@nl

type

label

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@en

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@nl

prefLabel

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@en

Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

@nl

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AJPATH.2009.080972

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The American Journal of Pathology

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Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation.

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Christopher Gully

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Hua Wang

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Huamin Wang

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Jian Chen

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Masanobu Kobayashi

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Mong-Hong Lee

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Ruiying Zhao

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Sai-Ching Jim Yeung

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Satoshi Kondo

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Stephanie Darmanin

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P2860

Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels

Physical and functional interactions between Pim-1 kinase and Cdc25A phosphatase. Implications for the Pim-1-mediated activation of the c-Myc signaling pathway

PAP-1, a novel target protein of phosphorylation by pim-1 kinase

Identification of heterochromatin protein 1 (HP1) as a phosphorylation target by Pim-1 kinase and the effect of phosphorylation on the transcriptional repression function of HP1(1)

Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus

Regulation of Pim-1 by Hsp90

The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

HIF-1 and tumor progression: pathophysiology and therapeutics

Pim-1 associates with protein complexes necessary for mitosis

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10.2353/AJPATH.2009.080972

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19528349

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