IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
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Knockdown of PKM2 and GLS1 expression can significantly reverse oxaliplatin-resistance in colorectal cancer cells.Glutamine Metabolism in Cancer: Understanding the Heterogeneity.Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.Context-Dependent Role of IKKβ in Cancer.Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis.Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.
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IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2016
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
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IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
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type
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IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
@en
IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
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prefLabel
IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
@en
IKKβ promotes metabolic adapta ...... tion and inhibition of PFKFB3.
@nl
P2093
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IKKβ promotes metabolic adapta ...... ation and inhibition of PFKFB3
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P2093
Mari B Ishak Gabra
Michael A Reid
Thai Q Tran
Xazmin H Lowman
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P304
P356
10.1101/GAD.287235.116
P577
2016-08-01T00:00:00Z