Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
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The notch ligand JAGGED1 as a target for anti-tumor therapyJagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.Slug is a direct Notch target required for initiation of cardiac cushion cellularizationHey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal heartsDifferential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeatsBiology of fibroblasts and myofibroblastsSmall C-terminal domain phosphatase enhances snail activity through dephosphorylationInhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARAMesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancersThe epithelial-mesenchymal transition: new insights in signaling, development, and diseaseDual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodelingEndothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and AngiogenesisKick it up a notch: Notch signaling and kidney fibrosisCirculating Tumor Cells: A Window Into Tumor Development and Therapeutic EffectivenessTracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancerImpact of notch signaling on inflammatory responses in cardiovascular disordersNotch: a key regulator of tumor angiogenesis and metastasisA role for partial endothelial-mesenchymal transitions in angiogenesis?Molecular mechanisms of epithelial-mesenchymal transitionAngiotensin II contributes to renal fibrosis independently of Notch pathway activationImpaired integrin β3 delays endothelial cell regeneration and contributes to arteriovenous graft failure in mice.Complexities of TGF-β targeted cancer therapy.TGF-β Signaling in Bone Remodeling and Osteosarcoma ProgressionCellular Plasticity in Prostate Cancer Bone MetastasisMechanisms of action of TGF-beta in cancer: evidence for Smad3 as a repressor of the hTERT geneEndothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndromeOxidative stress and glutathione in TGF-beta-mediated fibrogenesisKLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancerDedifferentiation of foetal CNS stem cells to mesendoderm-like cells through an EMT processThe transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancerTGF-beta-induced epithelial to mesenchymal transitionTargeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylationMechanistic exploration of phthalimide neovascular factor 1 using network analysis tools.Preventive effect of Notch signaling inhibition by a gamma-secretase inhibitor on peritoneal dialysis fluid-induced peritoneal fibrosis in ratsSmad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses.Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases.ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expressionDecreased levels of active SMAD2 correlate with poor prognosis in gastric cancer.BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivoDissection of the transformation of primary human hematopoietic cells by the oncogene NUP98-HOXA9
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Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 19 February 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Integration of TGF-beta/Smad a ...... lial-to-mesenchymal transition
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Integration of TGF-beta/Smad a ...... ial-to-mesenchymal transition.
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type
label
Integration of TGF-beta/Smad a ...... lial-to-mesenchymal transition
@en
Integration of TGF-beta/Smad a ...... ial-to-mesenchymal transition.
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prefLabel
Integration of TGF-beta/Smad a ...... lial-to-mesenchymal transition
@en
Integration of TGF-beta/Smad a ...... ial-to-mesenchymal transition.
@nl
P2093
P2860
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P1476
Integration of TGF-beta/Smad a ...... lial-to-mesenchymal transition
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P2093
Erwin P Böttinger
Jiri Zavadil
Lukas Cermak
Noemi Soto-Nieves
P2860
P304
P356
10.1038/SJ.EMBOJ.7600069
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P577
2004-02-19T00:00:00Z