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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

http://www.wikidata.org/entity/Q37260295

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IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization XIAP is not required for human tumor cell survival in the absence of an exogenous death signal Cadmium down-regulates expression of XIAP at the post-transcriptional level in prostate cancer cells through an NF-kappaB-independent, proteasome-mediated mechanism.Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy.A potential role of X-linked inhibitor of apoptosis protein in mitochondrial membrane permeabilization and its implication in cancer therapy The enigmatic roles of caspases in tumor development X-linked inhibitor of apoptosis protein and its E3 ligase activity promote transforming growth factor-{beta}-mediated nuclear factor-{kappa}B activation during breast cancer progression XIAP as a ubiquitin ligase in cellular signaling.IAPs on the move: role of inhibitors of apoptosis proteins in cell migration.Elevated XIAP expression alone does not confer chemoresistance.IAPs as E3 ligases of Rac1: shaping the move.Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.

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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

http://www.wikidata.org/entity/Q37260295

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 08 February 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.

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type

label

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

@en

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.

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prefLabel

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

@en

X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model.

@nl

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Cell Death & Differentiation

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X-linked inhibitor of apoptosis deficiency in the TRAMP mouse prostate cancer model

@en

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C Hwang

http://www.w3.org/2001/XMLSchema#string

C S Duckett

http://www.w3.org/2001/XMLSchema#string

D Kosoff

http://www.w3.org/2001/XMLSchema#string

K A Oetjen

http://www.w3.org/2001/XMLSchema#string

K J Wojno

http://www.w3.org/2001/XMLSchema#string

R L Dunn

http://www.w3.org/2001/XMLSchema#string

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The Hallmarks of Cancer

X-linked IAP is a direct inhibitor of cell-death proteases

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols.

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity.

Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

Down-regulation of X-linked inhibitor of apoptosis protein induces apoptosis in chemoresistant human ovarian cancer cells.

Characterization of XIAP-deficient mice.

Targeting XIAP for the treatment of malignancy.

XIAP: apoptotic brake and promising therapeutic target.

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831-840

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scholarly article

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10.1038/CDD.2008.15

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5

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15

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Kathleen A. Cooney

Diane M. Robins

Megan A Albertelli

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2008-02-08T00:00:00Z

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5593413

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18259199

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apoptotic process

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2710036

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