Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
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USP22 mediates the multidrug resistance of hepatocellular carcinoma via the SIRT1/AKT/MRP1 signaling pathway.m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation Program.ESE3 Inhibits Pancreatic Cancer Metastasis by Upregulating E-Cadherin.Loss of KLF4 and consequential downregulation of Smad7 exacerbate oncogenic TGF-β signaling in and promote progression of hepatocellular carcinoma.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer.Highlights from the Literature.Pharmacological targeting of apelin impairs glioblastoma growth.Nuclear GSK3β induces DNA double-strand break repair by phosphorylating 53BP1 in glioblastoma.Gli1-induced deubiquitinase USP48 aids glioblastoma tumorigenesis by stabilizing Gli1.Potential signaling pathways as therapeutic targets for overcoming chemoresistance in mucinous ovarian cancer.Apelin, the Devil Inside Brain Tumors.Stress-induced phosphoprotein 1 acts as a scaffold protein for glycogen synthase kinase-3 beta-mediated phosphorylation of lysine-specific demethylase 1.Casein kinase 1α: biological mechanisms and theranostic potential.KDM1A microenvironment, its oncogenic potential, and therapeutic significance.KDM5B demethylates H3K4 to recruit XRCC1 and promote chemoresistance.FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3β-related pathwaysPotential Strategies Overcoming the Temozolomide Resistance for GlioblastomaUbiquitin Regulation: The Histone Modifying Enzyme's Story
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Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 08 August 2016
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
@cs
name
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@en
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
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type
label
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@en
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@nl
prefLabel
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@en
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@nl
P2093
P2860
P50
P356
P1433
P1476
Nuclear GSK3β promotes tumorig ...... its deubiquitylation by USP22.
@en
P2093
Aidong Zhou
Jianfei Xue
Kenneth D Aldape
Keping Xie
Suyun Huang
Yaohui Chen
Zhongyong Wang
P2860
P2888
P304
P356
10.1038/NCB3396
P577
2016-08-08T00:00:00Z
P6179
1033504834