Filamin A is essential for active cell stiffening but not passive stiffening under external force
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Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-timeVinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission.A viscoelastic-stochastic model of the effects of cytoskeleton remodelling on cell adhesionFilamin structure, function and mechanics: are altered filamin-mediated force responses associated with human disease?Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces.Evidence of a large-scale mechanosensing mechanism for cellular adaptation to substrate stiffness.Compression and dilation of the membrane-cortex layer generates rapid changes in cell shape.Biomembrane-mimicking lipid bilayer system as a mechanically tunable cell substrate.Surprisingly simple mechanical behavior of a complex embryonic tissue.Direct detection of cellular adaptation to local cyclic stretching at the single cell level by atomic force microscopy.Filamins in mechanosensing and signaling.Actin filament length tunes elasticity of flexibly cross-linked actin networks.Stress transmission within the cellCell shape and substrate rigidity both regulate cell stiffnessMeasuring the mechanical properties of living cells using atomic force microscopyThe filamins: organizers of cell structure and functionAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Differential mechanical stability of filamin A rod segments.Contractile forces contribute to increased glycosylphosphatidylinositol-anchored receptor CD24-facilitated cancer cell invasion.Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.Physics and the canalization of morphogenesis: a grand challenge in organismal biology.Focal adhesion kinase stabilizes the cytoskeleton.Spatiotemporal relationships between the cell shape and the actomyosin cortex of periodically protruding cells.Complex roles of filamin-A mediated cytoskeleton network in cancer progression.The actin crosslinking protein palladin modulates force generation and mechanosensitivity of tumor associated fibroblasts.Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis.Plectin contributes to mechanical properties of living cells.Augmentation of integrin-mediated mechanotransduction by hyaluronic acid.Conformational changes and signaling in cell and matrix physicsFocal adhesion kinase activity is required for actomyosin contractility-based invasion of cells into dense 3D matrices.Cytokinesis through biochemical-mechanical feedback loops.The role of the tissue microenvironment in the regulation of cancer cell motility and invasion.Filamin A mediates interactions between cytoskeletal proteins that control cell adhesion.Nanomechanics of vascular endothelium.Mechanics of biological networks: from the cell cytoskeleton to connective tissue.Forcing cells into shape: the mechanics of actomyosin contractility.Filamin A: Insights into its Exact Role in Cancers.Cancer cells become less deformable and more invasive with activation of β-adrenergic signaling.Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration.Cobalt, titanium and PMMA bone cement debris influence on mouse osteoblast cell elasticity, spring constant and calcium production activity.
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P2860
Filamin A is essential for active cell stiffening but not passive stiffening under external force
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Filamin A is essential for act ...... tiffening under external force
@en
Filamin A is essential for act ...... iffening under external force.
@nl
type
label
Filamin A is essential for act ...... tiffening under external force
@en
Filamin A is essential for act ...... iffening under external force.
@nl
prefLabel
Filamin A is essential for act ...... tiffening under external force
@en
Filamin A is essential for act ...... iffening under external force.
@nl
P2093
P2860
P50
P1433
P1476
Filamin A is essential for act ...... tiffening under external force
@en
P2093
P2860
P304
P356
10.1016/J.BPJ.2009.02.035
P407
P577
2009-05-01T00:00:00Z