Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. - Wikidata - wikimedia - TriplyDB

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

http://www.wikidata.org/entity/Q37267118

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Genetically modified human bone marrow derived mesenchymal stem cells for improving the outcome of human islet transplantation miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression The central role of calcium in the effects of cytokines on beta-cell function: implications for type 1 and type 2 diabetes Islet inflammation: a unifying target for diabetes treatment?Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells The immunosuppressive role of adenosine A2A receptors in ischemia reperfusion injury and islet transplantation.Circulating levels of IL-1B+IL-6 cause ER stress and dysfunction in islets from prediabetic male mice.Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.Transgenic overexpression of active calcineurin in beta-cells results in decreased beta-cell mass and hyperglycemia.Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency.Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5.Synthesis of a novel suppressor of beta-cell apoptosis via diversity-oriented synthesis Exposure to the viral by-product dsRNA or Coxsackievirus B5 triggers pancreatic beta cell apoptosis via a Bim / Mcl-1 imbalance.Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation.Phagocyte-like NADPH oxidase promotes cytokine-induced mitochondrial dysfunction in pancreatic β-cells: evidence for regulation by Rac1.miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic α cells to cytokine-induced apoptosis as compared to β cells Caspase-3 is involved in IFN-γ- and TNF-α-mediated MIN6 cells apoptosis via NF-κB/Bcl-2 pathway.In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.Protective effect of calpain inhibitor N-acetyl-L-leucyl-L-leucyl-L-norleucinal on acute alcohol consumption related cardiomyopathy.STAT1-mediated down-regulation of Bcl-2 expression is involved in IFN-γ/TNF-α-induced apoptosis in NIT-1 cells.Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation.Prunella vulgaris aqueous extract attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.Cytokines Regulate β-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways JNK1/2 regulates ER-mitochondrial Ca2+ cross-talk during IL-1β-mediated cell death in RINm5F and human primary β-cells Small-molecule inhibitors of cytokine-mediated STAT1 signal transduction in β-cells with improved aqueous solubility Immune-mediated β-cell death in type 1 diabetes: lessons from human β-cell lines LIGHT/IFN-γ triggers β cells apoptosis via NF-κB/Bcl2-dependent mitochondrial pathway.Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function.MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes.Histone deacetylase (HDAC) inhibition as a novel treatment for diabetes mellitus.Regulation of pancreatic β-cell survival by nitric oxide: clinical relevance.Protein phosphatases in pancreatic islets.JNK1 Deficient Insulin-Producing Cells Are Protected against Interleukin-1β-Induced Apoptosis Associated with Abrogated Myc Expression.TRPM2-mediated rise in mitochondrial Zn(2+) promotes palmitate-induced mitochondrial fission and pancreatic β-cell death in rodents.Bufalin Induces Apoptosis of Human Osteosarcoma U-2 OS Cells through Endoplasmic Reticulum Stress, Caspase- and Mitochondria-Dependent Signaling Pathways.Ghrelin's Effects on Proinflammatory Cytokine Mediated Apoptosis and Their Impact on β-Cell Functionality.

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Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

http://www.wikidata.org/entity/Q37267118

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 26 May 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@en

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@nl

type

label

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@en

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@nl

prefLabel

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@en

Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@nl

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Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells.

@en

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Dusica Maysinger

http://www.w3.org/2001/XMLSchema#string

Lars G Grunnet

http://www.w3.org/2001/XMLSchema#string

Lawrence Rosenberg

http://www.w3.org/2001/XMLSchema#string

Lykke Blaabjerg

http://www.w3.org/2001/XMLSchema#string

Morten F Tonnesen

http://www.w3.org/2001/XMLSchema#string

Reid Aikin

http://www.w3.org/2001/XMLSchema#string

Steven Paraskevas

http://www.w3.org/2001/XMLSchema#string

P2860

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Cell death: critical control points

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

Beta-cell maturation leads to in vitro sensitivity to cytotoxins

Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons

The biochemistry of apoptosis

Cellular survival: a play in three Akts

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1807-1815

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scholarly article

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10.2337/DB08-0178

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8

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58

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Nils Billestrup

Thomas Mandrup-Poulsen

Joachim Størling

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2009-05-26T00:00:00Z

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26242063

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19470609

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apoptotic process

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2712790

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