T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
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Signaling in Effector Lymphocytes: Insights toward Safer ImmunotherapyMemory T Cell MigrationThe Gαq/11 proteins contribute to T lymphocyte migration by promoting turnover of integrin LFA-1 through recyclingPI3Kδ promotes CD4(+) T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1.The Immunogenetics of Autoimmune CholestasisARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated AdhesionThe N terminus of SKAP55 enables T cell adhesion to TCR and integrin ligands via distinct mechanisms.PIPKI gamma 90 negatively regulates LFA-1-mediated adhesion and activation in antigen-induced CD4+ T cells.Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal.Cognate antigen directs CD8+ T cell migration to vascularized transplantsImmune adaptor ADAP in T cells regulates HIV-1 transcription and cell-cell viral spread via different co-receptorsActin polymerization-dependent activation of Cas-L promotes immunological synapse stabilityNDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization.ADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.TLR signaling paralyzes monocyte chemotaxis through synergized effects of p38 MAPK and global Rap-1 activationGlycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8(+) Cytolytic T Cell Responses.The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation.Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy.Microenvironmental Control of High-Speed Interstitial T Cell Migration in the Lymph Node.Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activitySTK4 regulates TLR pathways and protects against chronic inflammation-related hepatocellular carcinoma.Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesionRap1 and its effector RIAM are required for lymphocyte trafficking.A role for Rap2 in recycling the extended conformation of LFA-1 during T cell migration.Multistage T cell-dendritic cell interactions control optimal CD4 T cell activation through the ADAP-SKAP55-signaling moduleProtein kinase A-dependent phosphorylation of Rap1 regulates its membrane localization and cell migrationSLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation.The insider's guide to leukocyte integrin signalling and function.The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.SKAP1 protein PH domain determines RapL membrane localization and Rap1 protein complex formation for T cell receptor (TCR) activation of LFA-1.The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy.D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formationAn atlas of mouse CD4(+) T cell transcriptomes.CD8+ Effector T Cell Migration to Pancreatic Islet Grafts Is Dependent on Cognate Antigen Presentation by Donor Graft CellsNon-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1.Lactobacillus plantarum Strains Can Enhance Human Mucosal and Systemic Immunity and Prevent Non-steroidal Anti-inflammatory Drug Induced Reduction in T Regulatory Cells.T-cell immune adaptor SKAP1 regulates the induction of collagen-induced arthritis in mice.
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P2860
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 25 March 2010
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en-gb
T cell receptor "inside-out" p ...... d interactions in lymph nodes.
@nl
type
label
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en-gb
T cell receptor "inside-out" p ...... d interactions in lymph nodes.
@nl
prefLabel
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en-gb
T cell receptor "inside-out" p ...... d interactions in lymph nodes.
@nl
P2093
P2860
P1433
P1476
T cell receptor "inside-out" p ...... nd interactions in lymph nodes
@en
P2093
Christopher E Rudd
Hongyan Wang
Klaus Strebhardt
Monika Raab
Zhonglin Wu
P2860
P304
P356
10.1016/J.IMMUNI.2010.03.007
P407
P577
2010-03-25T00:00:00Z