Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
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RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory elementPioneer transcription factors: establishing competence for gene expressionThe Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?Epigenetic mechanisms and developmental choice hierarchies in T-lymphocyte developmentCell-type-specific activation and repression of PU.1 by a complex of discrete, functionally specialized cis-regulatory elementsHistone arginine methylation keeps RUNX1 target genes in an intermediate state.A zinc-finger transcriptional activator designed to interact with the gamma-globin gene promoters enhances fetal hemoglobin production in primary human adult erythroblastsStudy of FoxA pioneer factor at silent genes reveals Rfx-repressed enhancer at Cdx2 and a potential indicator of esophageal adenocarcinoma developmentThe Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells.Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specificationOrigin, development, and homeostasis of tissue-resident macrophages.PU.1-mediated upregulation of CSF1R is crucial for leukemia stem cell potential induced by MOZ-TIF2Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities.Dynamic regulation of transcriptional states by chromatin and transcription factors.Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis.C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and MyelopoiesisRUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.RUNX1 induces DNA replication independent of active DNA demethylation at SPI1 regulatory regions.RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis.Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation.RUNX1a enhances hematopoietic lineage commitment from human embryonic stem cells and inducible pluripotent stem cellsDistinct temporal requirements for Runx1 in hematopoietic progenitors and stem cells.Identification of the microRNA networks contributing to macrophage differentiation and functionEpigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine.The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis.Hematopoietic stem cell emergence in the conceptus and the role of Runx1.Multilayered specification of the T-cell lineage fate.The hemangioblast: from concept to authentication.T cell lineage commitment: identity and renunciation.Establishing the stem cell state: insights from regulatory network analysis of blood stem cell development.The chromatin landscape and transcription factors in T cell programming.The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 functionEukaryotic enhancers: common features, regulation, and participation in diseases.The RUNX1-PU.1 axis in the control of hematopoiesis.Runx1 Structure and Function in Blood Cell Development.Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation.A matter of time - How transient transcription factor interactions create dynamic gene regulatory networks.Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action.The Role of Runx1 in Embryonic Blood Cell Formation.
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P2860
Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on April 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Early chromatin unfolding by R ...... ietic gene expression program.
@en
Early chromatin unfolding by R ...... ietic gene expression program.
@nl
type
label
Early chromatin unfolding by R ...... ietic gene expression program.
@en
Early chromatin unfolding by R ...... ietic gene expression program.
@nl
prefLabel
Early chromatin unfolding by R ...... ietic gene expression program.
@en
Early chromatin unfolding by R ...... ietic gene expression program.
@nl
P2093
P2860
P1433
P1476
Early chromatin unfolding by R ...... ietic gene expression program.
@en
P2093
Amanda Fisher
Andrew Williamson
Christophe Lancrin
Constanze Bonifer
Daniel G Tenen
Deborah Clarke
Georges Lacaud
Hanna Krysinska
Helle Jorgensen
Luca Mazzarella
P2860
P304
P356
10.1182/BLOOD-2008-11-191890
P407
P577
2009-04-01T00:00:00Z