A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO - Wikidata - wikimedia - TriplyDB

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

http://www.wikidata.org/entity/Q37274456

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Animal models of leukemia: any closer to the real thing?An integrated Drosophila model system reveals unique properties for F14512, a novel polyamine-containing anticancer drug that targets topoisomerase II An in vivo RNA interference screen identifies gene networks controlling Drosophila melanogaster blood cell homeostasis CalpB modulates border cell migration in Drosophila egg chambers.Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.A Guide to Genome-Wide In Vivo RNAi Applications in Drosophila.RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis.Calpain A modulates Toll responses by limited Cactus/IκB proteolysis.Drosophila as a model to study the role of blood cells in inflammation, innate immunity and cancer.In Vivo RNAi-Based Screens: Studies in Model Organisms.Drosophila: a model for studying genetic and molecular aspects of haematopoiesis and associated leukaemias AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches.Pontin is a critical regulator for AML1-ETO-induced leukemia.Esculetin Downregulates the Expression of AML1-ETO and C-Kit in Kasumi-1 Cell Line by Decreasing Half-Life of mRNA.Drosophila hematopoiesis under normal conditions and in response to immune stress.A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in Drosophila.Acute myeloid leukemia with the t(8;21) translocation: clinical consequences and biological implications.Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

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A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

http://www.wikidata.org/entity/Q37274456

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 July 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

A Drosophila model identifies ...... ogenic fusion protein AML1-ETO

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A Drosophila model identifies ...... genic fusion protein AML1-ETO.

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type

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A Drosophila model identifies ...... ogenic fusion protein AML1-ETO

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A Drosophila model identifies ...... genic fusion protein AML1-ETO.

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A Drosophila model identifies ...... ogenic fusion protein AML1-ETO

@en

A Drosophila model identifies ...... genic fusion protein AML1-ETO.

@nl

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PNAS.0902449106

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Proceedings of the National Academy of Sciences of the United States of America

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A Drosophila model identifies ...... ogenic fusion protein AML1-ETO

@en

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Dani Osman

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Frida Ponthan

http://www.w3.org/2001/XMLSchema#string

Lucas Waltzer

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Marc Haenlin

http://www.w3.org/2001/XMLSchema#string

Olaf Heidenreich

http://www.w3.org/2001/XMLSchema#string

Vanessa Gobert

http://www.w3.org/2001/XMLSchema#string

P2860

The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript

The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells

Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt

Core-binding factors in hematopoiesis and immune function

Oncogenic pathways of AML1-ETO in acute myeloid leukemia: multifaceted manipulation of marrow maturation.

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia.

Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis.

The 8;21 translocation in leukemogenesis.

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12043-12048

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scholarly article

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10.1073/PNAS.0902449106

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2009-07-06T00:00:00Z

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26651397

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19581587

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2715513

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