Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species. - Wikidata - wikimedia - TriplyDB

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

http://www.wikidata.org/entity/Q37275151

about

Metabolism of kidney cancer: from the lab to clinical practice Hypoxia-inducible factors and the response to hypoxic stress State of the science: an update on renal cell carcinoma Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?Targeted therapeutic strategies for the management of renal cell carcinoma Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect The complexity of the Nrf2 pathway: beyond the antioxidant response Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion Metabolic reprogramming for producing energy and reducing power in fumarate hydratase null cells from hereditary leiomyomatosis renal cell carcinoma Role of mitochondrial dysfunction in cancer progression Integrative gene expression profiling reveals G6PD-mediated resistance to RNA-directed nucleoside analogues in B-cell neoplasms Warburg effect's manifestation in aggressive pheochromocytomas and paragangliomas: insights from a mouse cell model applied to human tumor tissue.Molecular markers of paragangliomas/pheochromocytomas UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer.Intracellular succinylation of 8-chloroadenosine and its effect on fumarate levels.The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin Up-regulation of mitochondrial antioxidation signals in ovarian cancer cells with aggressive biologic behavior.Molecular diagnosis and therapy of kidney cancer.The genetic basis of kidney cancer: a metabolic disease The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling Aerobic glycolysis: a novel target in kidney cancer.Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase.NRF2 and cancer: the good, the bad and the importance of context.Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer.Increasing reactive oxygen species as a therapeutic approach to treat hereditary leiomyomatosis and renal cell carcinoma Exploring a glycolytic inhibitor for the treatment of an FH-deficient type-2 papillary RCC The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.Emerging metabolic targets in cancer therapy Fumarate induces redox-dependent senescence by modifying glutathione metabolism.New insights into the biology of renal cell carcinoma The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels.Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.Adrenal nodular hyperplasia in hereditary leiomyomatosis and renal cell cancer Molecular pathways: Fumarate hydratase-deficient kidney cancer--targeting the Warburg effect in cancer.Aerobic glycolysis tunes YAP/TAZ transcriptional activity The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells.Cellular metabolism and disease: what do metabolic outliers teach us?RHOBTB3 promotes proteasomal degradation of HIFα through facilitating hydroxylation and suppresses the Warburg effect.A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer.Modeling dioxygenase enzyme kinetics in familial paraganglioma.

P2860

Q24600512-2CADCC1D-810F-4892-8F51-38AA650DF82F Q24629323-5F12C967-EBA9-415E-AA16-2F314AC1A94D Q24630685-4A236E25-C0FA-4A0D-AD1F-B939636AD9DD Q26852282-1F964CD9-719B-4DEF-9341-46DC43721878 Q27013846-65A7D13B-3130-4467-B101-9AAD072E288E Q27024293-5E58FFEC-93A3-4E4D-A202-0C7C5A545485 Q28389296-C45A3E7C-6608-4876-B9CE-DC2115A17B61 Q28478577-2CA35E1B-D3BB-4811-8440-1F244953163B Q28535371-5F78C23B-61B0-47B0-AEE7-3EF2440BD20C Q28829644-DC6AF5DA-7B5F-4714-8C40-AF26B9D96845 Q31077729-AFC4C334-12BA-4C7E-A082-9E64B72E7F4F Q31079334-2EE43A2C-1C77-452D-85EB-155441C6175E Q33649025-A18A5A81-6C30-4EB6-A21D-AD64229D8196 Q33682182-EFB23A22-9FEE-434E-8755-C821A9D13E3C Q33707009-45AFC710-CA3B-45ED-911E-2BFEF75CF52F Q33816437-301A3910-5698-42A9-8282-DE9681C253C3 Q33884481-49978E74-84C9-4518-BE75-C96AF1BDC9FF Q34065685-9E398903-6507-4F1C-A7B1-2E79792E4B2A Q34087148-13E6AEAB-0CE0-4368-8AC9-F9B5E17EECC9 Q34107403-330A6228-7351-4A1D-847F-7F2850505592 Q34194088-56CAE70E-C791-4796-9210-7420B7325DAC Q34208791-2D7A1534-4B2A-4E13-8500-F99E71E656F8 Q34289003-BC6075BB-81E0-45E3-8A87-CDD786B3B8F3 Q34336619-E7B4FC62-92E0-4265-9826-C33ECCE6F50E Q34659918-3D514762-ACB6-468C-B6A5-685A24F8C4C7 Q34663243-5458495F-2F3B-4F49-9022-D15DE8836B74 Q34762767-B176AE38-FBA6-45A1-A7B5-A445C1637955 Q35052021-79CE980C-BD4E-4D38-A82A-D1C7E5D84257 Q35121732-259339D1-2B8B-4076-A6C0-BE196232C912 Q35180400-5EA50E6A-6254-4B1B-842C-E611E9417ADE Q35215557-2743E7AF-5D95-498B-B613-A700FFE65039 Q35278899-13E20F5D-CB24-4ED0-9D21-A64EB3AD92F4 Q35619919-C83660CE-F18C-4F60-BA05-E945791DD250 Q35659640-E13940DF-D41D-4534-87DB-3DDCDD79632F Q35819661-E11114ED-FFC7-4C99-A5E8-80BA46F42654 Q35889790-BFC04889-E79C-4592-B275-B39FB30B2778 Q35915928-AC37DC0D-98B3-48E1-B1AC-EE064167A831 Q36026989-CCAE7ACC-D2C6-4A91-A496-58439B5E7663 Q36153426-FDD209D7-7562-48F4-AD50-7913D547DAFF Q36175345-6ECEEF49-8598-408E-BD96-3FF94BBC78D7

P2860

Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and hypoxia-inducible transcription factor 1alpha stabilization by glucose-dependent generation of reactive oxygen species.

http://www.wikidata.org/entity/Q37275151

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 26 May 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@en

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@nl

type

label

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@en

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@nl

prefLabel

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@en

Fumarate hydratase deficiency ...... on of reactive oxygen species.

@nl

P1433

Q37275151-0BAC87BB-39A0-4654-AE63-AAFD8067DF6C

P1476

Q37275151-CE9C7941-105B-450D-8778-263A36C5CDC8

P2093

Q37275151-43D736DB-0AF8-4F13-BF24-AED63210171E

Q37275151-518F1A3B-90DF-4BC8-919C-ACBA8B3599B4

Q37275151-53ECAB8E-058E-4287-965E-0C46F223967A

Q37275151-5554FE0C-9921-4439-9498-7B175BB1BC55

Q37275151-63364AB9-090D-4900-AA4C-D639C086F3A4

Q37275151-94094B2D-DA98-4E38-95B7-EFBC500C08D0

Q37275151-9BF9648F-69F7-4137-8543-EAC821386286

Q37275151-9F949877-B623-48DA-BBCC-E032CF3B3F9F

Q37275151-AD990330-25A9-41F0-A1BF-7D16D86B3FEE

Q37275151-AE7F1E4B-5875-4329-8361-1620ED6C8876

P2860

Q37275151-04A95FCD-E9E9-4266-8EED-55CE343B6094

Q37275151-09559B7B-1C89-4EC3-9709-6FC5351623A0

Q37275151-0AF20C8F-9088-4F54-A9A4-0954A10ECBFA

Q37275151-11AFC3BF-9B41-4677-AC57-A4F5F31164BD

Q37275151-24BB7924-C366-4BA2-B473-517BBEFCDD8C

Q37275151-2F3A65FB-796D-41BB-A0D2-23518231CAA2

Q37275151-2F49CF0E-7C02-4F8F-BBEB-4CAF3F65462B

Q37275151-34F84DBD-EFD4-4E1D-B46F-6D7DB6B26270

Q37275151-3D97C0FF-0394-47E9-ABF5-BA03A852311E

Q37275151-47F8B197-5A26-4D17-8A8E-03997E4A3222

P304

Q37275151-7213C6F1-7F21-4352-B85C-3657610BA893

P31

Q37275151-FD1E438B-DCEB-492C-96E3-DC7CBAC720C1

P356

Q37275151-6AAE8EB8-5945-447D-8DB8-2C97ADC39E52

P407

Q37275151-1C990DC7-76B0-478E-9BD9-A74DA6285FAC

P433

Q37275151-D38B6035-F26B-4FCF-880B-71900AF798F3

P478

Q37275151-29CC5CA2-3133-45FD-A87F-F6CC10DD3A51

P50

Q37275151-B93EBF96-C3D3-4D9C-9C68-45F04DC67376

P577

Q37275151-8FE634BA-0842-428B-A4C3-6918EE98FA10

P698

Q37275151-7E6C3BB9-4569-42DF-B9D5-703FE1AF4D0B

P921

Q37275151-54423233-C696-44C3-B5BA-B03B4EB99030

Q37275151-B29B5DC5-FBE8-48FE-9F32-8410FB4CF035

Q37275151-b0c2c2ce-50e4-4d14-aadf-756915813bc9

P932

Q37275151-E381B912-E3FE-4C54-A6DC-2053C14DE159

P356

P1433

Molecular and Cellular Biology

P1476

Fumarate hydratase deficiency ...... ion of reactive oxygen species

@en

P2093

Bradley Scroggins

http://www.w3.org/2001/XMLSchema#string

Carole Sourbier

http://www.w3.org/2001/XMLSchema#string

Cynthia Galindo

http://www.w3.org/2001/XMLSchema#string

Hye-Sik Kong

http://www.w3.org/2001/XMLSchema#string

Jane Trepel

http://www.w3.org/2001/XMLSchema#string

Karen Block

http://www.w3.org/2001/XMLSchema#string

Len Neckers

http://www.w3.org/2001/XMLSchema#string

Mehdi Mollapour

http://www.w3.org/2001/XMLSchema#string

Min-Jung Lee

http://www.w3.org/2001/XMLSchema#string

Norman Goode

http://www.w3.org/2001/XMLSchema#string

P2860

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

A conserved family of prolyl-4-hydroxylases that modify HIF

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

On the Origin of Cancer Cells

Mitochondrial tumour suppressors: a genetic and biochemical update

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway

P304

4080-4090

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1128/MCB.00483-09

http://www.w3.org/2001/XMLSchema#string

P407

P433

15

http://www.w3.org/2001/XMLSchema#string

P478

29

http://www.w3.org/2001/XMLSchema#string

P50

Campbell W. Gourlay

P577

2009-05-26T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

19470762

http://www.w3.org/2001/XMLSchema#string

P921

P932

2715796

http://www.w3.org/2001/XMLSchema#string