MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development
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Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish modelsThe zebrafish as a model for studying neuroblastomaTh-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.Ultrastructural features of neuroblastic tumours in relation to morphological, and molecular findings; a retrospective review study.The prenatal origins of cancerDidymin: an orally active citrus flavonoid for targeting neuroblastoma.PHOX2B-mediated regulation of ALK expression: in vitro identification of a functional relationship between two genes involved in neuroblastoma.Preclinical models for neuroblastoma: establishing a baseline for treatmentWild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cellsCiliary neurotrophic factor reduces the proliferation and promotes the differentiation of TH- MYCN transformed sympathoadrenal progenitors.Functional dissection of HOXD cluster genes in regulation of neuroblastoma cell proliferation and differentiation.Essential role of GATA3 in regulation of differentiation and cell proliferation in SK-N-SH neuroblastoma cellsGeneration of murine sympathoadrenergic progenitor-like cells from embryonic stem cells and postnatal adrenal glands.Expression of MYCN in Multipotent Sympathoadrenal Progenitors Induces Proliferation and Neural Differentiation, but Is Not Sufficient for Tumorigenesis.Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.MycN Is Critical for the Maintenance of Human Embryonic Stem Cell-Derived Neural Crest Stem CellsThe chromatin remodeler chd5 is necessary for proper head development during embryogenesis of Danio rerio.Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.Neuroblastoma models for insights into tumorigenesis and new therapies.PHOX2A and PHOX2B are differentially regulated during retinoic acid-driven differentiation of SK-N-BE(2)C neuroblastoma cell line.Towards diagnostic application of non-coding RNAs in neuroblastoma.A transplantable TH-MYCN transgenic tumor model in C57Bl/6 mice for preclinical immunological studies in neuroblastoma.The MYCN Protein in Health and Disease.HOXC9 links cell-cycle exit and neuronal differentiation and is a prognostic marker in neuroblastomaTranscriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells.Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum.Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.Targeting of PHOX2B expression allows the identification of drugs effective in counteracting neuroblastoma cell growth.From proliferation to target innervation: signaling molecules that direct sympathetic nervous system development.Hey1- and p53-dependent TrkC proapoptotic activity controls neuroblastoma growth.
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MYCN promotes the expansion of Phox2B-positive neuronal progenitors to drive neuroblastoma development
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 16 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
MYCN promotes the expansion of ...... rive neuroblastoma development
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MYCN promotes the expansion of ...... ive neuroblastoma development.
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MYCN promotes the expansion of ...... rive neuroblastoma development
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MYCN promotes the expansion of ...... ive neuroblastoma development.
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MYCN promotes the expansion of ...... rive neuroblastoma development
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MYCN promotes the expansion of ...... ive neuroblastoma development.
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P2093
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MYCN promotes the expansion of ...... rive neuroblastoma development
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Goleeta Alam
Han-Fei Ding
Hongjuan Cui
Huilin Shi
Liqun Yang
William A Maltese
P2860
P304
P356
10.2353/AJPATH.2009.090019
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P577
2009-07-16T00:00:00Z