Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).
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Gene Dosage Effects at the Imprinted Gnas ClusterTransgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivoDeletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cisPotent constitutive cyclic AMP-generating activity of XLαs implicates this imprinted GNAS product in the pathogenesis of McCune-Albright syndrome and fibrous dysplasia of bone.Gsα enhances commitment of mesenchymal progenitors to the osteoblast lineage but restrains osteoblast differentiation in mice.Extra-long Gαs variant XLαs protein escapes activation-induced subcellular redistribution and is able to provide sustained signalingLoss of XLαs (extra-large αs) imprinting results in early postnatal hypoglycemia and lethality in a mouse model of pseudohypoparathyroidism Ib.The G protein α subunit variant XLαs promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo.Inherited human diseases of heterotopic bone formation.Parathyroid hormone signaling via Gαs is selectively inhibited by an NH(2)-terminally truncated Gαs: implications for pseudohypoparathyroidism.An siRNA screen identifies the GNAS locus as a driver in 20q amplified breast cancer.Different roles of GNAS and cAMP signaling during early and late stages of osteogenic differentiation.Large G protein α-subunit XLαs limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo.The curious case of Gαs gain-of-function in neoplasia.
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Extralarge XL(alpha)s (XXL(alpha)s), a variant of stimulatory G protein alpha-subunit (Gs(alpha)), is a distinct, membrane-anchored GNAS product that can mimic Gs(alpha).
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article científic
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bilimsel makale
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scientific article published on 07 May 2009
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Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
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Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
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Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
@en
Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
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Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
@en
Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
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Extralarge XL(alpha)s (XXL(alp ...... duct that can mimic Gs(alpha).
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Alpaslan Dedeoglu
Cumhur Aydin
Hesham A W Tawfeek
Mathew J Mahon
Murat Bastepe
Neil W Kowall
Nurgul Aytan
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P304
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10.1210/EN.2009-0318
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P577
2009-05-07T00:00:00Z