EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors.
about
GPCRs in stem cell functionThe epidermal growth factor receptor variant III (EGFRvIII): where wild things are alteredPigment Epithelium-Derived Factor (PEDF) Expression Induced by EGFRvIII Promotes Self-renewal and Tumor Progression of Glioma Stem Cells.Primary brain tumors, neural stem cell, and brain tumor cancer cells: where is the link?A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.Improved protein arrays for quantitative systems analysis of the dynamics of signaling pathway interactions.Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres.PTEN Tumor Suppressor Network in PI3K-Akt Pathway ControlAmplified and homozygously deleted genes in glioblastoma: impact on gene expression levelsThe G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Immune therapeutic targeting of glioma cancer stem cells.Whole genome sequencing of glioblastoma multiforme identifies multiple structural variations involved in EGFR activationGrowth factor dependent regulation of centrosome function and genomic instability by HuR.A clinical overview of centrosome amplification in human cancers.Aptamer targeting EGFRvIII mutant hampers its constitutive autophosphorylation and affects migration, invasion and proliferation of glioblastoma cells.Significance of filamin A in mTORC2 function in glioblastomaTRIM28 Is an E3 Ligase for ARF-Mediated NPM1/B23 SUMOylation That Represses Centrosome AmplificationEffect of EGFR and p-AKT Overexpression on Chromosomal Instability in Gastric Cancer.Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas.Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Pediatric glioma stem cells: biologic strategies for oncolytic HSV virotherapyInsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma.The PTEN-Akt pathway impacts the integrity and composition of mitotic centrosomesTurning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways.No association between phosphatase and tensin homolog genetic polymorphisms and colon cancerTranslational up-regulation of Aurora-A in EGFR-overexpressed cancerTargeted therapy for malignant glioma patients: lessons learned and the road ahead.Cancer stem cells: cell culture, markers, and targets for new therapies.A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth.Therapeutic targeting of EGFR in malignant gliomas.GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity.Glioma stem cell signaling: therapeutic opportunities and challenges.MicroRNAs as regulators of neural stem cell-related pathways in glioblastoma multiforme.Therapeutic targeting of EGFR-activated metabolic pathways in glioblastoma.Non-coding RNAs as epigenetic regulator of glioma stem-like cell differentiation.EGFR-dependent mechanisms in glioblastoma: towards a better therapeutic strategy.Implications of mitogen-activated protein kinase signaling in glioma.EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation.Targeting the fanconi anemia pathway to identify tailored anticancer therapeutics.Something old and something new about molecular diagnostics in gliomas.
P2860
Q27003270-E45836C8-B7F4-4FD5-953E-E5DD55345876Q27015045-71AAF87B-CA7E-489A-88BD-EE496E5D25EFQ30393905-02900BA1-2ED1-449D-BCC4-B8A3FCC7711DQ33729734-153AF585-04AC-4DFF-AE6E-0B695F7930ECQ33900952-B4294931-90F0-494A-B725-C7CBDE8D32A5Q34019542-C8829A7F-3C98-46A9-88E7-F887932EC628Q34037067-5DE4F4BC-CA30-4046-B7C7-0F6FFBF021D8Q34202681-664B8E83-BD0D-475B-B4CE-20EB9BE81899Q34430791-5F6CF5DA-1AB5-4C57-83DC-3F3788CC3348Q34573625-5E2CDADA-C5EF-4CDC-858D-7A99B36919DBQ34676437-A4B04063-C871-441D-9EFE-C70772CD6276Q35221471-FD0A8C55-083C-44F4-B174-6B3FC437C4A9Q35255512-4B374D51-07D4-4D3E-9B49-B5AD08E41C92Q35479894-C42FD511-6A41-4288-930C-873248AB9964Q35804765-9239B9C1-24F2-46D3-90C3-EBB9D4322B57Q35809950-15ED3665-7531-46DF-BD1C-860FBF16EA2FQ35868379-2974FA8A-C762-4F1F-B7EB-AD2EF259B2EBQ35915145-C15D57A7-742D-4163-8E46-D0FC10BF5AC1Q36087220-CA1D5903-B021-4179-8274-48BD04407AD6Q36280796-AC9CD889-39CA-4E89-AE59-D4FF3E7BDD40Q36644898-DCEB4676-15A2-4B78-A30A-8F735764B2D3Q36759183-D12F6DBE-02A7-4ABB-ADD6-E12FC1DCBDA4Q36906204-C9F57F9D-9FBB-49BF-A34E-A9EA89C24A49Q37285008-B30F573A-2B9A-4621-858A-377B141C038DQ37304241-0C690298-F02B-4554-BED3-F89E264BB954Q37310991-42DE0A3B-92AA-4BBB-A9B5-A12B55615C0DQ37533648-BDD936A9-4993-4C72-831D-AA43A8986FC5Q37598736-2FE8E4F8-1052-4A0B-9120-DAF6CADBD529Q37612660-59D26C30-30F2-478E-8450-EF7F637CA2DFQ37690755-023B8AB9-ACBA-42C9-AB2A-8F77DD09C58AQ37694758-BEBE094F-65E8-4F64-A3BF-BB14FFA1BA63Q37752381-5ED41BE3-D3A5-420B-8F5A-80BF4B33DAA3Q37897499-6841934D-63F6-4FFF-90DD-049F5EF2968AQ38111449-4C5F6BBD-01B0-43E8-854C-7282BFBC9B74Q38189361-A4E786C4-EA59-46A1-8D65-8CDD97B29A6FQ38199643-4C832EE2-660A-4AC5-91F9-EBC64B519C1BQ38618205-E096EF33-1EA4-4327-9E37-E6FF33885DF6Q38765219-570C6671-FB1F-4C7A-9C0B-D1C7E1885EF3Q42055866-D604E0CD-0E9F-497D-B374-E2F1931F1DEEQ43238974-534F34D4-3CA7-4827-90BE-5E9D7582F82E
P2860
EGFRvIII expression and PTEN loss synergistically induce chromosomal instability and glial tumors.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 23 September 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@en
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@nl
type
label
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@en
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@nl
prefLabel
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@en
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@nl
P2093
P2860
P1433
P1476
EGFRvIII expression and PTEN l ...... instability and glial tumors.
@en
P2093
Alonzo H Ross
Amalia Dutra
Evgenia Pak
Joseph E Labrie
Larry D Recht
Rachel M Gerstein
P2860
P356
10.1215/15228517-2008-081
P577
2008-09-23T00:00:00Z