Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618 - Wikidata - wikimedia - TriplyDB

Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618

Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618

http://www.wikidata.org/entity/Q37285546

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New strategies to maximize therapeutic opportunities for NAMPT inhibitors in oncology Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells Structural basis for resistance to diverse classes of NAMPT inhibitors Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid.EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition Depletion of the central metabolite NAD leads to oncosis-mediated cell death.Metabolic Response to NAD Depletion across Cell Lines Is Highly Variable Extensive regulation of nicotinate phosphoribosyltransferase (NAPRT) expression in human tissues and tumors.Supplementation of nicotinic acid with NAMPT inhibitors results in loss of in vivo efficacy in NAPRT1-deficient tumor models.Cancer subclonal genetic architecture as a key to personalized medicine.Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma.Cardiotoxicity Associated with Nicotinamide Phosphoribosyltransferase Inhibitors in Rodents and in Rat and Human-Derived Cells Lines.Nicotinamide phosphoribosyltransferase (Nampt) in carcinogenesis: new clinical opportunities.Retinal toxicity, in vivo and in vitro, associated with inhibition of nicotinamide phosphoribosyltransferase.Integrated Metabolomics and Proteomics Highlight Altered Nicotinamide- and Polyamine Pathways in Lung Adenocarcinoma.NAMPT suppresses glucose deprivation-induced oxidative stress by increasing NADPH levels in breast cancer.Novel NAPRT specific antibody identifies small cell lung cancer and neuronal cancers as promising clinical indications for a NAMPT inhibitor/niacin co-administration strategy.Preclinical efficacy of the novel competitive NAMPT inhibitor STF-118804 in pancreatic cancer.Quantitative Analysis of NAD Synthesis-Breakdown Fluxes.

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Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-618

http://www.wikidata.org/entity/Q37285546

description

article científic

@ca

article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2013

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618

@en

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618.

@nl

type

label

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618

@en

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618.

@nl

prefLabel

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618

@en

Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618.

@nl

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Dependence of tumor cell lines ...... NAMPT inhibition with GNE-618

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Bianca M Liederer

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Chris DelNagro

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Deepak Sampath

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Jarrod Tremayne

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Jason Oeh

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Jenni K Durieux

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Kristi Elkins

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Lisa D Belmont

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Lulu X Yang

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10.1593/NEO.131304

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