Variable var transition rates underlie antigenic variation in malaria
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Immune selection and within-host competition can structure the repertoire of variant surface antigens in Plasmodium falciparum--a mathematical modelAcquired immunity to malariaAntigenic variation in Plasmodium falciparum: gene organization and regulation of the var multigene familyExpression of Plasmodium falciparum erythrocyte membrane protein 1 in experimentally infected humansPlasmodium falciparum variant surface antigen expression patterns during malariaTranscriptome analysis of antigenic variation in Plasmodium falciparum--var silencing is not dependent on antisense RNAMutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production.The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria ParasitesSurface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1Exonuclease-mediated degradation of nascent RNA silences genes linked to severe malariaA genetically hard-wired metabolic transcriptome in Plasmodium falciparum fails to mount protective responses to lethal antifolatesA Unique Virulence Gene Occupies a Principal Position in Immune Evasion by the Malaria Parasite Plasmodium falciparumSir2 paralogues cooperate to regulate virulence genes and antigenic variation in Plasmodium falciparumIdentification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells.Clonal variants of Plasmodium falciparum exhibit a narrow range of rolling velocities to host receptor CD36 under dynamic flow conditions.Patterns of gene recombination shape var gene repertoires in Plasmodium falciparum: comparisons of geographically diverse isolates.Default Pathway of var2csa switching and translational repression in Plasmodium falciparumAntigenic variation in Plasmodium falciparum malaria involves a highly structured switching patternInvestigating the host binding signature on the Plasmodium falciparum PfEMP1 protein family.Erasing the epigenetic memory and beginning to switch--the onset of antigenic switching of var genes in Plasmodium falciparumInduction of strain-transcending antibodies against Group A PfEMP1 surface antigens from virulent malaria parasites.A statistically rigorous method for determining antigenic switching networks.P. falciparum infection durations and infectiousness are shaped by antigenic variation and innate and adaptive host immunity in a mathematical model.Phenotypic and functional profiling of CD4 T cell compartment in distinct populations of healthy adults with different antigenic exposureHow malaria parasites avoid running out of ammo.Plasmodium falciparum var gene silencing is determined by cis DNA elements that form stable and heritable interactions.Transcription of the var genes from a freshly-obtained field isolate of Plasmodium falciparum shows more variable switching patterns than long laboratory-adapted isolates.Dissecting the determinants of malaria chronicity: why within-host models struggle to reproduce infection dynamicsHigh-throughput screening platform identifies small molecules that prevent sequestration of Plasmodium falciparum-infected erythrocytes.Epigenetic memory at malaria virulence genes.Molecular epidemiology of malaria.A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytesDevelopmental stage- and cell cycle number-dependent changes in characteristics of Plasmodium falciparum-infected erythrocyte adherence to placental chondroitin-4-sulfate proteoglycan.Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections.Serum lipoproteins promote efficient presentation of the malaria virulence protein PfEMP1 at the erythrocyte surface.In Vitro Variant Surface Antigen Expression in Plasmodium falciparum Parasites from a Semi-Immune Individual Is Not Correlated with Var Gene Transcription.Antigen presentation and dendritic cell biology in malaria.Var transcription profiling of Plasmodium falciparum 3D7: assignment of cytoadherent phenotypes to dominant transcripts.Unusual chromatin structure associated with monoparalogous transcription of the Babesia bovis ves multigene family.Plasmodium falciparum antigenic variation. Mapping mosaic var gene sequences onto a network of shared, highly polymorphic sequence blocks
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Variable var transition rates underlie antigenic variation in malaria
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 15 July 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Variable var transition rates underlie antigenic variation in malaria
@en
Variable var transition rates underlie antigenic variation in malaria.
@nl
type
label
Variable var transition rates underlie antigenic variation in malaria
@en
Variable var transition rates underlie antigenic variation in malaria.
@nl
prefLabel
Variable var transition rates underlie antigenic variation in malaria
@en
Variable var transition rates underlie antigenic variation in malaria.
@nl
P2093
P2860
P356
P1476
Variable var transition rates underlie antigenic variation in malaria
@en
P2093
Robert Pinches
Sue A Kyes
Zóe Christodoulou
P2860
P304
11129-11134
P356
10.1073/PNAS.0402347101
P407
P577
2004-07-15T00:00:00Z