Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation
about
Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke TherapyDelivery of drugs bound to erythrocytes: new avenues for an old intravascular carrierTargeting of a mutant plasminogen activator to circulating red blood cells for prophylactic fibrinolysisRed blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the nSustained thromboprophylaxis mediated by an RBC-targeted pro-urokinase zymogen activated at the site of clot formation.Targeted thrombolysis strategies for neuroprotective effectAnnexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke.Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy.tPA contributes to impairment of ATP and Ca sensitive K channel mediated cerebrovasodilation after hypoxia/ischemia through upregulation of ERK MAPK.PAI-1-derived peptide EEIIMD prevents hypoxia/ischemia-induced aggravation of endothelin- and thromboxane-induced cerebrovasoconstriction.Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic/ischemic injury via extracellular signal-regulated kinase/mitogen-activated protein kinase in pigletsSignaling, delivery and age as emerging issues in the benefit/risk ratio outcome of tPA For treatment of CNS ischemic disorders.RBC-coupled tPA Prevents Whereas tPA Aggravates JNK MAPK-Mediated Impairment of ATP- and Ca-Sensitive K Channel-Mediated Cerebrovasodilation After Cerebral PhotothrombosisAdvanced drug delivery systems for antithrombotic agents.Drug delivery by red blood cells: vascular carriers designed by mother nature.Vascular targeting of antithrombotic agents.Approaches to erythrocyte-mediated drug delivery.Erythrocytes-based synthetic delivery systems: transition from conventional to novel engineering strategies.Red blood cells: Supercarriers for drugs, biologicals, and nanoparticles and inspiration for advanced delivery systems.Erythrocytes as Carriers for Drug Delivery in Blood Transfusion and Beyond.
P2860
Q26777274-9509CDC0-5D18-4B65-9D79-A482055D9F35Q26801300-A8D90F13-9585-4198-A21B-0F8590DED088Q33714889-E16B829F-051C-4E0B-A951-40E8D3836A1AQ33734359-A8F817D0-87B9-44E6-8126-0EB1AA2F7C52Q33944248-826E395A-F463-4E70-B02B-6A6455826F75Q34163191-33943530-4760-493C-93FE-5E29F6BB2969Q34171180-CB58F0BC-A356-42BB-9AC0-4B81E2F2EE14Q34363696-111F12B6-4006-4855-842F-FF60C177D342Q34570654-0D63644E-45BA-4B92-94A5-485937BE4B61Q35580953-2132C880-BCF0-4E24-8E2B-E933CE6745A6Q35799306-87AB36D8-A428-4056-820D-90F816E3109FQ36307742-2C285B2D-E1BF-44E9-A8A6-79E86AFD0364Q36748046-FFEB8F89-7A04-4956-A41B-CF4FCBB474CBQ37132620-2B067236-54BE-423D-AAA9-F9C8623548D4Q37700751-4794B1F4-AE44-463B-9629-75FD3FB0E0B3Q37902114-E29DE036-2751-43CA-A025-09A8772FF4BFQ38189095-BFEE883B-ACF5-45B3-B64B-180ECD2FBC38Q38218799-C33E5117-223B-4B0D-95CD-4CD6406CD1CBQ38760096-879F9F9D-8BA4-4DEA-B8EC-1C8D7E541462Q38972974-B62BFD80-9FB5-4C79-A882-7C445C3008C8
P2860
Red blood cells-coupled tPA prevents impairment of cerebral vasodilatory responses and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK activation
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 13 May 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Red blood cells-coupled tPA pr ...... ibition of ERK MAPK activation
@en
Red blood cells-coupled tPA pr ...... bition of ERK MAPK activation.
@nl
type
label
Red blood cells-coupled tPA pr ...... ibition of ERK MAPK activation
@en
Red blood cells-coupled tPA pr ...... bition of ERK MAPK activation.
@nl
prefLabel
Red blood cells-coupled tPA pr ...... ibition of ERK MAPK activation
@en
Red blood cells-coupled tPA pr ...... bition of ERK MAPK activation.
@nl
P2093
P2860
P356
P1476
Red blood cells-coupled tPA pr ...... ibition of ERK MAPK activation
@en
P2093
Abd A R Higazi
Douglas B Cines
Douglas H Smith
John W Kiessling
Khalil Bdeir
Kumkum Ganguly
Sergei Zaitsev
Vladimir R Muzykantov
William M Armstead
Xiao-Han Chen
P2860
P304
P356
10.1038/JCBFM.2009.61
P577
2009-05-13T00:00:00Z