Nitroxyl (HNO): the Cinderella of the nitric oxide story.
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Novel Perspectives in Redox Biology and Pathophysiology of Failing Myocytes: Modulation of the Intramyocardial Redox Milieu for Therapeutic Interventions-A Review Article from the Working Group of Cardiac Cell Biology, Italian Society of CardiologyNitroxyl (HNO): A Reduced Form of Nitric Oxide with Distinct Chemical, Pharmacological, and Therapeutic PropertiesA critical review of pharmacological significance of Hydrogen Sulfide in hypertensionA tale of two gases: NO and H2S, foes or friends for life?Signaling and stress: The redox landscape in NOS2 biologyThe nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activationNitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway.Reactions of HNO with heme proteins: new routes to HNO-heme complexes and insight into physiological effects.Proton-induced reactivity of NO⁻ from a {CoNO}⁸ complexNitroxyl (HNO) stimulates soluble guanylyl cyclase to suppress cardiomyocyte hypertrophy and superoxide generation.Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation propertiesNitroxyl (HNO) reacts with molecular oxygen and forms peroxynitrite at physiological pH. Biological Implications.The chemistry of nitroxyl-releasing compounds.New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregationDesign and Synthesis of Near-infrared Fluorescent Probes for Imaging of Biological Nitroxyl.Ring expansions of acyloxy nitroso compoundsPharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects.The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats.Recent advances in the chemical biology of nitroxyl (HNO) detection and generation.Nitroxyl donors retain their depressor effects in hypertension.Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides.A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries.cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.The effects of nitroxyl (HNO) on H₂O₂ metabolism and possible mechanisms of HNO signaling.Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using β-galactosidase.The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms.Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention.Sickle cell anemia and vascular dysfunction: the nitric oxide connection.Cardiac inotropes: current agents and future directions.Ruthenium complexes as NO donors for vascular relaxation induction.Discriminative EPR detection of NO and HNO by encapsulated nitronyl nitroxides.Angeli's Salt, a nitroxyl anion donor, reverses endothelin-1 mediated vascular dysfunction in murine aorta.A Phase 2a dose-escalation study of the safety, tolerability, pharmacokinetics and haemodynamic effects of BMS-986231 in hospitalized patients with heart failure with reduced ejection fraction.Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure.Stem cells and diabetic cardiomyopathy: from pathology to therapy.The chemical biology of HNO signaling.Visualization of nitroxyl (HNO) in vivo via a lysosome-targetable near-infrared fluorescent probe.Agents with vasodilator properties in acute heart failure.A fast-response, highly sensitive and selective fluorescent probe for the ratiometric imaging of nitroxyl in living cells.Sulfonimidamides in Medicinal and Agricultural Chemistry.
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P2860
Nitroxyl (HNO): the Cinderella of the nitric oxide story.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Nitroxyl (HNO): the Cinderella of the nitric oxide story.
@en
type
label
Nitroxyl (HNO): the Cinderella of the nitric oxide story.
@en
prefLabel
Nitroxyl (HNO): the Cinderella of the nitric oxide story.
@en
P2093
P1476
Nitroxyl (HNO): the Cinderella of the nitric oxide story.
@en
P2093
Barbara K Kemp-Harper
Jennifer C Irvine
Joanne L Favaloro
Karen L Andrews
Rebecca H Ritchie
Robert E Widdop
P304
P356
10.1016/J.TIPS.2008.08.005
P577
2008-10-01T00:00:00Z