Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.
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Molecular aspects of thyroid hormone actionsMulti-tissue gene-expression analysis in a mouse model of thyroid hormone resistanceClinical Consequences of Mutations in Thyroid Hormone Receptor-α1Role and Mechanisms of Actions of Thyroid Hormone on the Skeletal DevelopmentHomozygous thyroid hormone receptor β-gene mutations in resistance to thyroid hormone: three new cases and review of the literature.CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse modelThyroid hormone--sympathetic interaction and adaptive thermogenesis are thyroid hormone receptor isoform--specificThyroid hormone signaling in vivo requires a balance between coactivators and corepressorsNuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signalingA dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.An unliganded thyroid hormone beta receptor activates the cyclin D1/cyclin-dependent kinase/retinoblastoma/E2F pathway and induces pituitary tumorigenesisApigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells.Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis.The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors.Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinomaLessons from mouse models of thyroid cancer.Genomic profiling of genes contributing to metastasis in a mouse model of thyroid follicular carcinoma.Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface.Anaplastic Thyroid Carcinoma: Current Treatments and Potential New Therapeutic Options with Emphasis on TfR1/CD71.Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone.Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene.Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer.A targeted dominant negative mutation of the thyroid hormone alpha 1 receptor causes increased mortality, infertility, and dwarfism in mice.Silencing of Wnt signaling and activation of multiple metabolic pathways in response to thyroid hormone-stimulated cell proliferation.Persistence of oligodendrocyte precursor cells and altered myelination in optic nerve associated to retina degeneration in mice devoid of all thyroid hormone receptorsThyroid hormone receptor α mutation causes a severe and thyroxine-resistant skeletal dysplasia in female mice.Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action.Direct development: an alternative way to make a frog.Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor.Synergistic signaling of KRAS and thyroid hormone receptor β mutants promotes undifferentiated thyroid cancer through MYC up-regulation.Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retinaThyroid hormone receptor beta (THRB) is a major target gene for microRNAs deregulated in papillary thyroid carcinoma (PTC)Pancreatic and Islet Development and Function: The Role of Thyroid Hormone.Activation of integrin-ERBB2 signaling in undifferentiated thyroid cancer.Characterization of skeletal phenotypes of TRalpha1 and TRbeta mutant mice: implications for tissue thyroid status and T3 target gene expressionOncogenic Actions of the Nuclear Receptor Corepressor (NCOR1) in a Mouse Model of Thyroid Cancer.Global expression profiling reveals gain-of-function oncogenic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis.Differential recruitment of nuclear coregulators directs the isoform-dependent action of mutant thyroid hormone receptors.
P2860
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P2860
Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Mice with a targeted mutation ...... resistance to thyroid hormone.
@en
Mice with a targeted mutation ...... resistance to thyroid hormone.
@nl
type
label
Mice with a targeted mutation ...... resistance to thyroid hormone.
@en
Mice with a targeted mutation ...... resistance to thyroid hormone.
@nl
prefLabel
Mice with a targeted mutation ...... resistance to thyroid hormone.
@en
Mice with a targeted mutation ...... resistance to thyroid hormone.
@nl
P2093
P2860
P356
P1476
Mice with a targeted mutation ...... resistance to thyroid hormone.
@en
P2093
A Wynshaw-Boris
B Weintraub
D G Pankratz
K Kaneshige
M C Willingham
M Kaneshige
R Kazlauskaite
P2860
P304
13209-13214
P356
10.1073/PNAS.230285997
P407
P577
2000-11-01T00:00:00Z