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Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

http://www.wikidata.org/entity/Q37288916

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MicroRNA-184 inhibits neuroblastoma cell survival through targeting the serine/threonine kinase AKT2 The myc-miR-17~92 axis blunts TGF{beta} signaling and production of multiple TGF{beta}-dependent antiangiogenic factors Clusterin facilitates stress-induced lipidation of LC3 and autophagosome biogenesis to enhance cancer cell survival Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma Lineage-specific restraint of pituitary gonadotroph cell adenoma growth.CLU blocks HDACI-mediated killing of neuroblastoma.Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells CASZ1, a candidate tumor-suppressor gene, suppresses neuroblastoma tumor growth through reprogramming gene expression.The tumour-suppressive function of CLU is explained by its localisation and interaction with HSP60.Neuroblastoma progress on many fronts: the Neuroblastoma Research Symposium.Addiction of MYCN amplified tumours to B-MYB underscores a reciprocal regulatory loop Two miRNA clusters, Mir-17-92 (Mirc1) and Mir-106b-25 (Mirc3), are involved in the regulation of spermatogonial differentiation in mice.Regulation of CLU gene expression by oncogenes and epigenetic factors implications for tumorigenesis.EZH2 Mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR Clusterin and FOXL2 act concordantly to regulate pituitary gonadotroph adenoma growth Targeting ALK in neuroblastoma--preclinical and clinical advancements.Identification of CASZ1 NES reveals potential mechanisms for loss of CASZ1 tumor suppressor activity in neuroblastoma.Clusterin is a gene-specific target of microRNA-21 in head and neck squamous cell carcinoma.Therapeutic targeting of miRNAs in neuroblastoma.Genetically engineered murine models--contribution to our understanding of the genetics, molecular pathology and therapeutic targeting of neuroblastoma.The role of genetic and epigenetic alterations in neuroblastoma disease pathogenesis.MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin.Evaluation of bone marrow as a metastatic site of human neuroblastoma.Neuroblastoma models for insights into tumorigenesis and new therapies.The CLU-files: disentanglement of a mystery.HBX Protein-Induced Downregulation of microRNA-18a is Responsible for Upregulation of Connective Tissue Growth Factor in HBV Infection-Associated Hepatocarcinoma Radiation-induced TNFα cross signaling-dependent nuclear import of NFκB favors metastasis in neuroblastoma.Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications.Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma.Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.Haploinsufficiency of Tumor Suppressor Genes is Driven by the Cumulative Effect of microRNAs, microRNA Binding Site Polymorphisms and microRNA Polymorphisms: An In silico Approach.MYCN is recruited to the RASSF1A promoter but is not critical for DNA hypermethylation in neuroblastoma.Genetic inactivation of ApoJ/clusterin: effects on prostate tumourigenesis and metastatic spread.

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Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

http://www.wikidata.org/entity/Q37288916

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 28 April 2009

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

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vědecký článek

@cs

name

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

@en

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

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type

label

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

@en

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

@nl

prefLabel

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

@en

Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

@nl

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Journal of the National Cancer Institute

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Clusterin, a haploinsufficient tumor suppressor gene in neuroblastomas.

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Alessandro E Caccamo

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Arturo Sala

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Daisy Corvetta

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Giorgia Santilli

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Izabela Piotrowska

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John Anderson

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Michael D Hogarty

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Michael Dews

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Nourredine Himoudi

http://www.w3.org/2001/XMLSchema#string

Olesya Chayka

http://www.w3.org/2001/XMLSchema#string

P2860

Human MicroRNA targets

Direct transactivation of the anti-apoptotic gene apolipoprotein J (clusterin) by B-MYB

Clusterin inhibits apoptosis by interacting with activated Bax

Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing

Myc represses transcription through recruitment of DNA methyltransferase corepressor

NF-kappa B contacts DNA by a heterodimer of the p50 and p65 subunit

c-Myc-regulated microRNAs modulate E2F1 expression

ONCOMINE: a cancer microarray database and integrated data-mining platform

Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.

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663-677

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scholarly article

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10.1093/JNCI/DJP063

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9

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101

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Andrei Thomas-Tikhonenko

Saverio Bettuzzi

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2009-04-28T00:00:00Z

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24376475

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19401549

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haploinsufficiency

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2720718

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