The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα.
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Von Willebrand factor-A1 domain binds platelet glycoprotein Ibα in multiple states with distinctive force-dependent dissociation kineticsCooperation within von Willebrand factors enhances adsorption mechanism.Platelet GpIba binding to von Willebrand Factor under fluid shear:contributions of the D′D3-domain, A1-domain flanking peptide and O-linked glycans.von Willebrand factor, Jedi knight of the bloodstreamExploiting the kinetic interplay between GPIbα-VWF binding interfaces to regulate hemostasis and thrombosisIdentification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex.Transport regulation of two-dimensional receptor-ligand associationForce-induced on-rate switching and modulation by mutations in gain-of-function von Willebrand diseases.Force-Induced Unfolding of Leucine-Rich Repeats of Glycoprotein Ibα Strengthens Ligand InteractionDifferential surface activation of the A1 domain of von Willebrand factor.Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals.Transport physics and biorheology in the setting of hemostasis and thrombosis.A biophysical view on von Willebrand factor activation.Flow-Enhanced Stability of Rolling Adhesion through E-Selectin.Two-Dimensional Analysis of Cross-Junctional Molecular Interaction by Force Probes.Fluorescence Biomembrane Force Probe: Concurrent Quantitation of Receptor-ligand Kinetics and Binding-induced Intracellular Signaling on a Single Cell.Flow-induced elongation of von Willebrand factor precedes tension-dependent activation.Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species.The physical spacing between the von willebrand factor d'd3- and a1- domains regulates platelet adhesion in vitro and in vivo.Receptor-mediated cell mechanosensing.Specific electrostatic interactions between charged amino acid residues regulate binding of von Willebrand factor to blood platelets.A discontinuous autoinhibitory module masks the A1 domain of von Willebrand factor.14-3-3 proteins in platelet biology and glycoprotein Ib-IX signaling.Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.Autoregulation of von Willebrand factor function by a disulfide bond switch.Mechano-redox control of integrin de-adhesion
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P2860
The N-terminal flanking region of the A1 domain regulates the force-dependent binding of von Willebrand factor to platelet glycoprotein Ibα.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 23 September 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
@en
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
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type
label
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
@en
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
@nl
prefLabel
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
@en
The N-terminal flanking region ...... to platelet glycoprotein Ibα.
@nl
P2093
P2860
P356
P1476
The N-terminal flanking region ...... r to platelet glycoprotein Ibα
@en
P2093
Jing-fei Dong
Miguel A Cruz
P2860
P304
32289-32301
P356
10.1074/JBC.M113.504001
P407
P50
P577
2013-09-23T00:00:00Z