The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. - Wikidata - wikimedia - TriplyDB

The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.

The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.

http://www.wikidata.org/entity/Q37292195

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ARF6-JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion.NEDD9/Arf6-dependent endocytic trafficking of matrix metalloproteinase 14: a novel mechanism for blocking mesenchymal cell invasion and metastasis of breast cancer.Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation Arf1 and Arf6 promote ventral actin structures formed by acute activation of protein kinase C and Src Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11-Rab8-mediated ciliary receptor targeting.High level expression of AMAP1 protein correlates with poor prognosis and survival after surgery of head and neck squamous cell carcinoma patients Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.ASAP1 promotes tumor cell motility and invasiveness, stimulates metastasis formation in vivo, and correlates with poor survival in colorectal cancer patients.GEP100/Arf6 is required for epidermal growth factor-induced ERK/Rac1 signaling and cell migration in human hepatoma HepG2 cells The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility.ARF1 regulates the Rho/MLC pathway to control EGF-dependent breast cancer cell invasion sZIP, an alternative splice variant of ZIP, antagonizes transcription repression and growth inhibition by ZIP Distinct gene expression profiles in subsets of chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors.Co-overexpression of GEP100 and AMAP1 proteins correlates with rapid local recurrence after breast conservative therapy Shigella flexneri regulation of ARF6 activation during bacterial entry via an IpgD-mediated positive feedback loop.Lymphovascular invasion and histologic grade are associated with specific genomic profiles in invasive carcinomas of the breast Inhibitory effect of ethanol extract of Ocimum sanctum on osteopontin mediated metastasis of NCI-H460 non-small cell lung cancer cells.Role for a Cindr-Arf6 axis in patterning emerging epithelia.ARF family G proteins and their regulators: roles in membrane transport, development and disease.ArfGAPs: key regulators for receptor sorting.The Role of ARF6 in Biliary Atresia.ARF6-mediated endocytic recycling impacts cell movement, cell division and lipid homeostasis.NotI microarrays: novel epigenetic markers for early detection and prognosis of high grade serous ovarian cancer.Phosphotyrosine recognition domains: the typical, the atypical and the versatile.The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors.Allosteric properties of PH domains in Arf regulatory proteins.Phosphorylation of the Bin, Amphiphysin, and RSV161/167 (BAR) domain of ACAP4 regulates membrane tubulation.No Significant Effect of ASAP1 Gene Variants on the Susceptibility to Tuberculosis in Chinese Population ZEB1 induces EPB41L5 in the cancer mesenchymal program that drives ARF6-based invasion, metastasis and drug resistance.Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.The biology of uveal melanoma Rab35: GEFs, GAPs and effectors.ADP ribosylation factor 6 (Arf6) acts through FilGAP protein to down-regulate Rac protein and regulates plasma membrane blebbing.Parametric Linkage Analysis Identifies Five Novel Genome-Wide Significant Loci for Familial Lung Cancer.Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.Arf proteins in cancer cell migration.AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions Long non-coding RNAs as novel biomarkers for breast cancer invasion and metastasis Arf6 in lymphatic endothelial cells regulates lymphangiogenesis by controlling directional cell migration.

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The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis.

http://www.wikidata.org/entity/Q37292195

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 21 April 2009

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@en

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@nl

type

label

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@en

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@nl

prefLabel

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@en

The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

@nl

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J.1600-0854.2009.00917.X

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The EGFR-GEP100-Arf6-AMAP1 sig ...... ancer invasion and metastasis.

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Ari Hashimoto

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Eiji Ogawa

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Hajime Yano

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Hisataka Sabe

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Jin-Min Nam

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Koichi Miura

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Masaki Morishige

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Shigeru Hashimoto

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Yasuhito Onodera

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Creative Commons Attribution 2.5 Unported

P2860

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src.

CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery

A role for POR1, a Rac1-interacting protein, in ARF6-mediated cytoskeletal rearrangements

Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis

CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors

The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.

A tubular EHD1-containing compartment involved in the recycling of major histocompatibility complex class I molecules to the plasma membrane

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10.1111/J.1600-0854.2009.00917.X

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transport protein

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breast neoplasm

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