Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production
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Systems Biology Approaches to Understand Natural Products BiosynthesisNovel B(12)-dependent acyl-CoA mutases and their biotechnological potential.Metabolic engineering for the production of natural products.Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination.Improvement of FK506 production in Streptomyces tsukubaensis by genetic enhancement of the supply of unusual polyketide extender units via utilization of two distinct site-specific recombination systems.Dissecting and engineering of the TetR family regulator SACE_7301 for enhanced erythromycin production in Saccharopolyspora erythraeaSystems perspectives on erythromycin biosynthesis by comparative genomic and transcriptomic analyses of S. erythraea E3 and NRRL23338 strains.Identification and characterization of a new erythromycin biosynthetic gene cluster in Actinopolyspora erythraea YIM90600, a novel erythronolide-producing halophilic actinomycete isolated from salt field.A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq.An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strainGenetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentationA key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraeaSACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.Production of microbial secondary metabolites: regulation by the carbon source.Carbon source regulation of antibiotic production.Engineering microbial hosts for production of bacterial natural productsTemporal dynamics of the Saccharopolyspora erythraea phosphoproteome.Improvement of chloramphenicol production in Streptomyces venezuelae ATCC 10712 by overexpression of the aroB and aroK genes catalysing steps in the shikimate pathway.Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production.Simultaneous production and partitioning of heterologous polyketide and isoprenoid natural products in an Escherichia coli two-phase bioprocess.A comparative metabolomics analysis of Saccharopolyspora spinosa WT, WH124, and LU104 revealed metabolic mechanisms correlated with increases in spinosad yield.TetR Family Transcriptional Regulator PccD Negatively Controls Propionyl Coenzyme A Assimilation in Saccharopolyspora erythraea.PccD regulates branched-chain amino acid degradation, and exerts a negative effect on erythromycin production in Saccharopolyspora erythraea.Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnem pretiosum.Metabolomics analysis of the effect of dissolved oxygen on spinosad production by Saccharopolyspora spinosa.Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum.Engineering of chromosomal wax ester synthase integrated Saccharomyces cerevisiae mutants for improved biosynthesis of fatty acid ethyl esters.A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253.SACE_3986, a TetR family transcriptional regulator, negatively controls erythromycin biosynthesis in Saccharopolyspora erythraea.Strain improvement and optimization studies for enhanced production of erythromycin in bagasse based medium using Saccharopolyspora erythraea MTCC 1103.
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P2860
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 March 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Engineering of the methylmalon ...... reased erythromycin production
@en
Engineering of the methylmalon ...... eased erythromycin production.
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type
label
Engineering of the methylmalon ...... reased erythromycin production
@en
Engineering of the methylmalon ...... eased erythromycin production.
@nl
prefLabel
Engineering of the methylmalon ...... reased erythromycin production
@en
Engineering of the methylmalon ...... eased erythromycin production.
@nl
P2093
P2860
P1476
Engineering of the methylmalon ...... reased erythromycin production
@en
P2093
Andrew R Reeves
Benjamin I Leach
Igor A Brikun
J Mark Weber
Melissa C Gonzalez
William H Cernota
P2860
P304
P356
10.1016/J.YMBEN.2007.02.001
P577
2007-03-24T00:00:00Z