Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? - Wikidata - wikimedia - TriplyDB

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

http://www.wikidata.org/entity/Q37296850

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Physical activity and genetic predisposition to obesity in a multiethnic longitudinal study Thinking evolutionarily about obesity Race, regionality and pre-diabetes in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study Revisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetes Examining How Our Shared Evolutionary History Shapes Future Disease Outcomes.Irrational use of antibiotics and the risk of diabetes in Ghana Positive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.Globalization of diabetes: the role of diet, lifestyle, and genes.Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?Shared ancestral susceptibility to colorectal cancer and other nutrition related diseases Polymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implications Natural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions.The importance of global studies of the genetics of type 2 diabetes.Genetics of Obesity: What have we Learned?Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians Evidence of Polygenic Adaptation in the Systems Genetics of Anthropometric Traits A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis Transferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus Study Evolutionary triangulation: informing genetic association studies with evolutionary evidence.Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospects The genetics of childhood obesity and interaction with dietary macronutrients Genetic Determinants of Type 2 Diabetes in Asians Signatures of natural selection on genetic variants affecting complex human traits.Adaptive genetic variation and heart disease risk.Genetics of type 2 diabetes in East Asian populations.Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits.Intrauterine Programming of Diabetes and Adiposity.Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.Evidence for natural selection at the melanocortin-3 receptor gene in European and African populations.Ethnic and population differences in the genetic predisposition to human obesity.Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.Behaviors and characteristics of African American and European American females that impact weight management.Variation at diabetes- and obesity-associated Loci may mirror neutral patterns of human population diversity and diabetes prevalence in India.A global evolutionary and metabolic analysis of human obesity gene risk variants.Evidence of selection at insulin receptor substrate-1 gene loci.On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression.

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Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

http://www.wikidata.org/entity/Q37296850

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scientific article published on 13 June 2009

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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Is the thrifty genotype hypoth ...... esity-susceptibility variants?

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L Southam

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M I McCarthy

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S B Montgomery

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T M Frayling

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A map of recent positive selection in the human genome

Common variants near MC4R are associated with fat mass, weight and risk of obesity

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

A second generation human haplotype map of over 3.1 million SNPs

Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

Genome-wide association studies in type 2 diabetes

Worldwide population differentiation at disease-associated SNPs.

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1846-1851

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9

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52

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Eleftheria Zeggini

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2009-06-13T00:00:00Z

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type-2 diabetes

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2723682

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