Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
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Physical activity and genetic predisposition to obesity in a multiethnic longitudinal studyThinking evolutionarily about obesityRace, regionality and pre-diabetes in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) studyRevisiting the thrifty gene hypothesis via 65 loci associated with susceptibility to type 2 diabetesExamining How Our Shared Evolutionary History Shapes Future Disease Outcomes.Irrational use of antibiotics and the risk of diabetes in GhanaPositive selection of protective variants for type 2 diabetes from the Neolithic onward: a case study in Central Asia.Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular diseaseType 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases.Globalization of diabetes: the role of diet, lifestyle, and genes.Can evidence from genome-wide association studies and positive natural selection surveys be used to evaluate the thrifty gene hypothesis in East Asians?Shared ancestral susceptibility to colorectal cancer and other nutrition related diseasesPolymorphisms in CTNNBL1 in relation to colorectal cancer with evolutionary implicationsNatural selection at genomic regions associated with obesity and type-2 diabetes: East Asians and sub-Saharan Africans exhibit high levels of differentiation at type-2 diabetes regions.The importance of global studies of the genetics of type 2 diabetes.Genetics of Obesity: What have we Learned?Signatures of natural selection at the FTO (fat mass and obesity associated) locus in human populations.β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East AsiansEvidence of Polygenic Adaptation in the Systems Genetics of Anthropometric TraitsA mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesisTransferability and fine mapping of type 2 diabetes loci in African Americans: the Candidate Gene Association Resource Plus StudyEvolutionary triangulation: informing genetic association studies with evolutionary evidence.Gene-environment and gene-treatment interactions in type 2 diabetes: progress, pitfalls, and prospectsThe genetics of childhood obesity and interaction with dietary macronutrientsGenetic Determinants of Type 2 Diabetes in AsiansSignatures of natural selection on genetic variants affecting complex human traits.Adaptive genetic variation and heart disease risk.Genetics of type 2 diabetes in East Asian populations.Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits.Intrauterine Programming of Diabetes and Adiposity.Pacific Populations, Metabolic Disease and 'Just-So Stories': A Critique of the 'Thrifty Genotype' Hypothesis in Oceania.Evidence for natural selection at the melanocortin-3 receptor gene in European and African populations.Ethnic and population differences in the genetic predisposition to human obesity.Colorectal cancer risk and patients' survival: influence of polymorphisms in genes somatically mutated in colorectal tumors.Behaviors and characteristics of African American and European American females that impact weight management.Variation at diabetes- and obesity-associated Loci may mirror neutral patterns of human population diversity and diabetes prevalence in India.A global evolutionary and metabolic analysis of human obesity gene risk variants.Evidence of selection at insulin receptor substrate-1 gene loci.On the origin of obesity: identifying the biological, environmental and cultural drivers of genetic risk among human populations.The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression.
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Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Is the thrifty genotype hypoth ...... esity-susceptibility variants?
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Is the thrifty genotype hypoth ...... esity-susceptibility variants?
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type
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Is the thrifty genotype hypoth ...... esity-susceptibility variants?
@en
Is the thrifty genotype hypoth ...... esity-susceptibility variants?
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prefLabel
Is the thrifty genotype hypoth ...... esity-susceptibility variants?
@en
Is the thrifty genotype hypoth ...... esity-susceptibility variants?
@nl
P2093
P2860
P50
P1433
P1476
Is the thrifty genotype hypoth ...... esity-susceptibility variants?
@en
P2093
M I McCarthy
S B Montgomery
T M Frayling
P2860
P2888
P304
P356
10.1007/S00125-009-1419-3
P577
2009-06-13T00:00:00Z