Lessons from computer simulations of Ras proteins in solution and in membrane
about
Principles and Overview of Sampling Methods for Modeling Macromolecular Structure and DynamicspMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound ProteinsIntrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motionsMechanisms of membrane binding of small GTPase K-Ras4B farnesylated hypervariable region.Binding hotspots on K-ras: consensus ligand binding sites and other reactive regions from probe-based molecular dynamics analysis.Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway.Overview of simulation studies on the enzymatic activity and conformational dynamics of the GTPase Ras.Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role.Nucleotide Dependent Switching in Rho GTPase: Conformational Heterogeneity and Competing Molecular Interactions.Direct Modulation of Small GTPase Activity and Function.Computational allosteric ligand binding site identification on Ras proteins.Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations.Probing the wild-type HRas activation mechanism using steered molecular dynamics, understanding the energy barrier and role of water in the activation.Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells.Spatiotemporal Analysis of K-Ras Plasma Membrane Interactions Reveals Multiple High Order Homo-oligomeric Complexes.
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P2860
Lessons from computer simulations of Ras proteins in solution and in membrane
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 30 July 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Lessons from computer simulations of Ras proteins in solution and in membrane
@en
Lessons from computer simulations of Ras proteins in solution and in membrane.
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type
label
Lessons from computer simulations of Ras proteins in solution and in membrane
@en
Lessons from computer simulations of Ras proteins in solution and in membrane.
@nl
prefLabel
Lessons from computer simulations of Ras proteins in solution and in membrane
@en
Lessons from computer simulations of Ras proteins in solution and in membrane.
@nl
P2860
P1476
Lessons from computer simulations of Ras proteins in solution and in membrane
@en
P2093
Alemayehu A Gorfe
Priyanka Prakash
P2860
P304
P356
10.1016/J.BBAGEN.2013.07.024
P407
P577
2013-07-30T00:00:00Z