Nucleoside analogs: molecular mechanisms signaling cell death.
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Purine analogues plus cyclophosphamide versus purine analogues alone for first-line therapy of patients with chronic lymphocytic leukaemiaThe sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesRegulation of deoxynucleotide metabolism in cancer: novel mechanisms and therapeutic implicationsCancer stem cells and drug resistance: the potential of nanomedicineNucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factorsIdentification of 5-Iodotubercidin as a genotoxic drug with anti-cancer potentialEmbryonic carcinoma cells show specific dielectric resistance profiles during induced differentiationDownregulation of deoxycytidine kinase in cytarabine-resistant mantle cell lymphoma cells confers cross-resistance to nucleoside analogs gemcitabine, fludarabine and cladribine, but not to other classes of anti-lymphoma agents.Efficient overcoming of drug resistance to anticancer nucleoside analogs by nanodelivery of active phosphorylated drugsAutophagy, Warburg, and Warburg reverse effects in human cancer.Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the antileukemia agent CNDAC.Borononucleotides as substrates/binders for human NMP kinases: enzymatic and spectroscopic evaluation.The synergistic cytotoxicity of clofarabine, fludarabine and busulfan in AML cells involves ATM pathway activation and chromatin remodelingHuman biodistribution and radiation dosimetry of novel PET probes targeting the deoxyribonucleoside salvage pathwayNovel PET probes specific for deoxycytidine kinase.Poly(ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.Oncogenic NRAS Primes Primary Acute Myeloid Leukemia Cells for DifferentiationDNA repair mechanisms in cancer development and therapyHybridization Properties of RNA Containing 8-Methoxyguanosine and 8-Benzyloxyguanosine.Requirement for transient metal ions revealed through computational analysis for DNA polymerase going in reverse.A Positive Selection for Nucleoside Kinases in E. coliEpigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.Progerin sequestration of PCNA promotes replication fork collapse and mislocalization of XPA in laminopathy-related progeroid syndromes.AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repairTargeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.8-Amino-adenosine activates p53-independent cell death of metastatic breast cancersPredicting enhanced cell killing through PARP inhibition.Mechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: relevance of p53 and its clinical implications.Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic modelDamage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activitySynergistic cytotoxicity of gemcitabine, clofarabine and edelfosine in lymphoma cell lines.Cidofovir: a novel antitumor agent for glioblastoma.Chk1 inhibition significantly potentiates activity of nucleoside analogs in TP53-mutated B-lymphoid cellsMetabolism and brain cancer.Present status and perspectives in functional analysis of p53 in chronic lymphocytic leukemia.New insights into the synergism of nucleoside analogs with radiotherapyEpigenetic modulating agents as a new therapeutic approach in multiple myeloma.Cytotoxic activity of the novel heterocyclic compound G-11 is primarily mediated through intrinsic apoptotic pathway.Mechanistic insights into epigenetic modulation of ethanol consumption.
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Nucleoside analogs: molecular mechanisms signaling cell death.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Nucleoside analogs: molecular mechanisms signaling cell death.
@en
Nucleoside analogs: molecular mechanisms signaling cell death.
@nl
type
label
Nucleoside analogs: molecular mechanisms signaling cell death.
@en
Nucleoside analogs: molecular mechanisms signaling cell death.
@nl
prefLabel
Nucleoside analogs: molecular mechanisms signaling cell death.
@en
Nucleoside analogs: molecular mechanisms signaling cell death.
@nl
P356
P1433
P1476
Nucleoside analogs: molecular mechanisms signaling cell death
@en
P2093
P2888
P304
P356
10.1038/ONC.2008.316
P407
P577
2008-10-01T00:00:00Z