A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.
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Apolipoprotein B is a new target of the GDNF/RET and ET-3/EDNRB signalling pathwaysAnimal models of age related macular degenerationAbundant lipid and protein components of drusenApolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration.Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).Expression of apolipoprotein B in the kidney attenuates renal lipid accumulationDNA methylation is associated with altered gene expression in AMD.Mice that produce ApoB100 lipoproteins in the RPE do not develop drusen yet are still a valuable experimental systemRegulation of the cholesterol efflux transporters ABCA1 and ABCG1 in retina in hemochromatosis and by the endogenous siderophore 2,5-dihydroxybenzoic acid.Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in miceNatural history of age-related retinal lesions that precede AMD in mice fed high or low glycemic index diets.Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress.The oil spill in ageing Bruch membrane.Aging is not a disease: distinguishing age-related macular degeneration from aging.Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration.Insights from human congenital disorders of intestinal lipid metabolism.The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype.Skeletal muscle apolipoprotein B expression reduces muscular triglyceride accumulation.Models of retinal diseases and their applicability in drug discovery.
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P2860
A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 07 February 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A human apoB100 transgenic mou ...... evelops features of early AMD.
@en
A human apoB100 transgenic mou ...... evelops features of early AMD.
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type
label
A human apoB100 transgenic mou ...... evelops features of early AMD.
@en
A human apoB100 transgenic mou ...... evelops features of early AMD.
@nl
prefLabel
A human apoB100 transgenic mou ...... evelops features of early AMD.
@en
A human apoB100 transgenic mou ...... evelops features of early AMD.
@nl
P2093
P2860
P1476
A human apoB100 transgenic mou ...... evelops features of early AMD.
@en
P2093
Emil Bartels
James T Handa
Lars B Nielsen
Masashi Fujihara
P2860
P304
P356
10.1016/J.EXER.2009.01.017
P577
2009-02-07T00:00:00Z