Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis.
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Metabolomics and diabetes: analytical and computational approachesThe organic anion transporter (OAT) family: a systems biology perspectiveOrganic anion and cation SLC22 "drug" transporter (Oat1, Oat3, and Oct1) regulation during development and maturation of the kidney proximal tubuleEvolutionary Analysis and Classification of OATs, OCTs, OCTNs, and Other SLC22 Transporters: Structure-Function Implications and Analysis of Sequence MotifsAn Integrated View of Aristolochic Acid Nephropathy: Update of the LiteratureInteraction of organic cations with organic anion transportersPotent inhibitors of human organic anion transporters 1 and 3 from clinical drug libraries: discovery and molecular characterizationAnalysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handlingTransmembrane peptide as potent inhibitor of oligomerization and function of human organic anion transporter 1.Remote communication through solute carriers and ATP binding cassette drug transporter pathways: an update on the remote sensing and signaling hypothesis.Functional maturation of drug transporters in the developing, neonatal, and postnatal kidney.Linkage of organic anion transporter-1 to metabolic pathways through integrated "omics"-driven network and functional analysis.Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1).α-Tocopherol injections in rats up-regulate hepatic ABC transporters, but not cytochrome P450 enzymesTranscriptome-based reconstructions from the murine knockout suggest involvement of the urate transporter, URAT1 (slc22a12), in novel metabolic pathwaysMultispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2.Short-term and long-term effects of protein kinase C on the trafficking and stability of human organic anion transporter 3Handling of Drugs, Metabolites, and Uremic Toxins by Kidney Proximal Tubule Drug Transporters.Shared Ligands Between Organic Anion Transporters (OAT1 and OAT6) and Odorant ReceptorsRegulation of human organic anion transporter 4 by parathyroid hormone-related protein and protein kinase AExpression and function of renal and hepatic organic anion transporters in extrahepatic cholestasis.Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis.Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy.What do drug transporters really do?Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue.Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1Three ubiquitination sites of organic anion transporter-1 synergistically mediate protein kinase C-dependent endocytosis of the transporter.Analysis of ABCG2 and other urate transporters in uric acid homeostasis in chronic kidney disease: potential role of remote sensing and signaling.Growth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway.Serum- and glucocorticoid-inducible kinase sgk2 stimulates the transport activity of human organic anion transporters 1 by enhancing the stability of the transporter.Kidney versus Liver Specification of SLC and ABC Drug Transporters, Tight Junction Molecules, and Biomarkers.Multispecific drug transporter Slc22a8 (Oat3) regulates multiple metabolic and signaling pathways.Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney diseaseHepatocyte nuclear factors 4α and 1α regulate kidney developmental expression of drug-metabolizing enzymes and drug transporters.Serum- and glucocorticoid-inducible kinase SGK2 regulates human organic anion transporters 4 via ubiquitin ligase Nedd4-2.An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3.The effects of acute renal failure on drug metabolism.The drug transporter OAT3 (SLC22A8) regulates endogenous metabolite flow through the gut-liver-kidney axis.Key Role for the Organic Anion Transporters, OAT1 and OAT3, in the in vivo Handling of Uremic Toxins and SolutesLoops and layers of post-translational modifications of drug transporters.
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Toward a systems level understanding of organic anion and other multispecific drug transporters: a remote sensing and signaling hypothesis.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 10 June 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Toward a systems level underst ...... sing and signaling hypothesis.
@en
Toward a systems level underst ...... sing and signaling hypothesis.
@nl
type
label
Toward a systems level underst ...... sing and signaling hypothesis.
@en
Toward a systems level underst ...... sing and signaling hypothesis.
@nl
prefLabel
Toward a systems level underst ...... sing and signaling hypothesis.
@en
Toward a systems level underst ...... sing and signaling hypothesis.
@nl
P2860
P356
P1476
Toward a systems level underst ...... sing and signaling hypothesis.
@en
P2093
Sanjay K Nigam
Sun-Young Ahn
P2860
P304
P356
10.1124/MOL.109.056564
P577
2009-06-10T00:00:00Z