Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
about
Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway.Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination StudiesThe IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis.The IGF-1R/AKT pathway determines cell fate in response to p53.p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a.HDAC inhibition as a treatment concept to combat temsirolimus-resistant bladder cancer cells.NVP-BEZ235 synergizes cisplatin sensitivity in osteosarcoma.MiR-30a-5p confers cisplatin resistance by regulating IGF1R expression in melanoma cells.TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production.p53 and metabolism: from mechanism to therapeutics.
P2860
Q36236493-CDE11D0C-3B9D-443D-853A-7308E551EEA0Q38641329-14D07C99-1D9C-4747-A150-233285003017Q38697577-F7FA7BC8-7D89-48EC-97E1-CDA8626E46A3Q41687394-2A0E42BE-EB00-412C-9F9D-7A8055BA0D9CQ46251110-E0BFC4D9-1B10-4902-A078-6D2FA0B2DFD6Q47100939-E6AC5E79-AE30-499B-B301-39B13AB290DDQ52657087-E8EFABF7-5FA6-41F1-B040-064991D3C5FFQ52720005-72FE772F-1B59-4F75-B3BF-9FA27F73F200Q53687206-10C85F2A-7C79-4AAE-8174-2B27D8A740A2Q55002919-371F94D0-E2C8-4BC4-A380-A0A188B142A2
P2860
Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 March 2016
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@en
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@nl
type
label
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@en
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@nl
prefLabel
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@en
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@nl
P2093
P2860
P356
P1433
P1476
Crosstalk between the IGF-1R/A ...... f an IGF-1R pathway inhibitor.
@en
P2093
Batzaya Davaadelger
Carl G Maki
Ricardo E Perez
Steven Gitelis
P2860
P304
27511-27526
P356
10.18632/ONCOTARGET.8484
P407
P577
2016-03-30T00:00:00Z