Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview. - Wikidata - wikimedia - TriplyDB

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

http://www.wikidata.org/entity/Q37318132

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Substandard drugs: a potential crisis for public health.Novel Nitrobenzazolo[3,2-a]quinolinium Salts Induce Cell Death through a Mechanism Involving DNA Damage, Cell Cycle Changes, and Mitochondrial Permeabilization Is nelfinavir exposure associated with cancer incidence in HIV-positive individuals?Comparing BMD-derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay.Development of the adverse outcome pathway "alkylation of DNA in male premeiotic germ cells leading to heritable mutations" using the OECD's users' handbook supplement.

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Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

http://www.wikidata.org/entity/Q37318132

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 06 August 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

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Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

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type

label

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

@en

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

@nl

prefLabel

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

@en

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

@nl

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AIDS Research and Therapy

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Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept, Roche): overview.

@en

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Anton Pozniak

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David Tweats

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Judith K Jones

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Lutz Müller

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Miklos Salgo

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Peter Larson

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P2860

Ethyl methanesulfonate toxicity in Viracept--a comprehensive human risk assessment based on threshold data for genotoxicity.

MGMT hypermethylation: a prognostic foe, a predictive friend.

What happened: the chemistry side of the incident with EMS contamination in Viracept tablets.

Mechanistic influences for mutation induction curves after exposure to DNA-reactive carcinogens.

In vivo genotoxicity of EMS: statistical assessment of the dose response curves.

Modelling of patient EMS exposure: translating pharmacokinetics of EMS in vitro and in animals into patients.

In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human.

MNT and MutaMouse studies to define the in vivo dose response relations of the genotoxicity of EMS and ENU.

General 4-week toxicity study with EMS in the rat.

In vivo studies in the mouse to define a threshold for the genotoxicity of EMS and ENU.

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scholarly article

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10.1186/1742-6405-6-18

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6

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2009-08-06T00:00:00Z

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1016881000

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19660105

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nelfinavir mesylate

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2731786

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