Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.

Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.

Item
http://www.wikidata.org/entity/Q37320288
Discovery of α,β- and α,γ-diamino acid scaffolds for the inhibition of M1 family aminopeptidasesThe Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach.Aminopeptidase N (CD13) as a target for cancer chemotherapy.An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling.Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases.Aminopeptidase N (EC 3.4.11.2) inhibitors (2006 - 2010): a patent review.Adeno-associated virus (AAV) vectors in cancer gene therapy.A particular expression pattern of CD13 epitope 7H5 in chronic lymphocytic leukaemia--a possible new therapeutic target.Design, synthesis and biological evaluation of novel L-isoserine tripeptide derivatives as aminopeptidase N inhibitors.Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors.LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin.Melflufen - a peptidase-potentiated alkylating agent in clinical trials.APN/CD13 is over-expressed by Psoriatic fibroblasts and is modulated by CGRP and IL-4 but not by retinoic acid treatment.The first ratiometric fluorescent probe for aminopeptidase N
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Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.

Item
http://www.wikidata.org/entity/Q37320288
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.
@en
Aminopeptidase N
@nl
type
label
Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.
@en
Aminopeptidase N
@nl
prefLabel
Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.
@en
Aminopeptidase N
@nl
P1433
P1476
P2093
P304
P31
P356
P433
P478
P577
P698
P356
P1433
P1476
Aminopeptidase N (APN/CD13) as a target for anti-cancer agent design.
@en
P2093
P304
P31
P356
10.2174/092986708786242840
P433
P478
P577
P698