Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
about
Sodium channel molecular conformations and antiarrhythmic drug affinityBisphenol A binds to the local anesthetic receptor site to block the human cardiac sodium channelProkaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonismFast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental studyClassification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp studyComparison of Gating Properties and Use-Dependent Block of Nav1.5 and Nav1.7 Channels by Anti-Arrhythmics Mexiletine and LidocaineMolecular mechanism of allosteric modification of voltage-dependent sodium channels by local anestheticsMolecular model of anticonvulsant drug binding to the voltage-gated sodium channel inner pore.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Molecular determinants of state-dependent block of voltage-gated sodium channels by pilsicainide.Lidocaine partially depolarizes the S4 segment in domain IV of the sodium channel.Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling.Use-dependent block of the voltage-gated Na(+) channel by tetrodotoxin and saxitoxin: effect of pore mutations that change ionic selectivity.Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels.Mutant bacterial sodium channels as models for local anesthetic block of eukaryotic proteinsModeling the human Nav1.5 sodium channel: structural and mechanistic insights of ion permeation and drug blockade.The sodium channel as a target for local anesthetic drugs.Molecular Pathophysiology of Congenital Long QT Syndrome.Multiple targets for flecainide action: implications for cardiac arrhythmogenesis.Local anesthetic inhibition of a bacterial sodium channelMolecular Insights into the Local Anesthetic Receptor within Voltage-Gated Sodium Channels Using Hydroxylated Analogs of Mexiletine.Voltage-dependent blockade by bupivacaine of cardiac sodium channels expressed in Xenopus oocytes.Membrane permeable local anesthetics modulate Na(V)1.5 mechanosensitivityRanolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.Molecular basis for class Ib anti-arrhythmic inhibition of cardiac sodium channels.The human Nav1.5 F1486 deletion associated with long QT syndrome leads to impaired sodium channel inactivation and reduced lidocaine sensitivity.Interaction of alfaxalone with the neuronal and the skeletal muscle sodium channel.State-dependent block of voltage-gated sodium channels by the casein-kinase 1 inhibitor IC261.Non-blocking modulation contributes to sodium channel inhibition by a covalently attached photoreactive riluzole analog.Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems
P2860
Q24595359-23905D2A-29F2-427A-AB40-97DF8F2A43D0Q27330612-AA59FC52-AF89-48E6-9BC1-F281797152F7Q27683885-D76B0ED2-51B4-486F-8299-1CF554060FCAQ28474487-5DD2FC5C-291B-4B3B-9F4C-EEFF8880F0F3Q28476574-1BBD5ECB-0D55-4C72-8999-E70BF18F8D4BQ28548133-E33076C4-DDBD-412E-B4AF-572EE1A49739Q34243052-8E979A14-74C9-4566-A080-7C9E016B801AQ34310101-3F980139-2709-484D-91DC-3A161BDD8E1DQ34409608-9BC81ACA-AC5B-483B-A8C8-0E74406228F0Q34621064-B17D0F12-53A6-4560-85A3-9161F62AB0CBQ34789375-94DC39A7-3C7B-4282-BBA9-766B989F70EBQ35764979-31F86A95-30D3-4CCE-8421-1DC7C5C29058Q36277894-B794F2AC-17C5-41BC-A806-0362D4A9A346Q36363379-E7BF9407-0E19-4AD4-86B6-B6FA391C142CQ37112043-738AAF98-DF79-4810-9C93-91ABEC42D056Q38613252-80D93C54-DDD2-4F89-86A8-A53A735484A8Q38890303-EA6FE694-A458-4126-9BD0-D88B332F66B8Q38997049-6A5F3162-E978-4A02-8535-9120E850BDA3Q39215625-3F42CD82-A59F-4B86-8AC0-30C34B522531Q39340842-8D9EB988-72D2-4496-8717-A3FD234B17BEQ41126715-66ABE05F-6301-40EC-BCAE-12467424C986Q41458203-97DD91E2-5201-41A6-BBE8-7952EF2DEF8FQ42111305-19148A94-DE19-474B-BC6C-366FFD75D4A0Q42768918-1FB8F3CB-751C-41D1-AD9E-36C06A93995FQ43427939-91DBAEB0-7DD8-4222-89E1-1EEF0774ABB7Q44714535-D65FEE01-AFE0-4978-9B98-DEE40F174B9BQ48166719-5DA3F0CD-90B3-42EE-A0A3-18CC68508859Q48274837-4185B526-A859-4A23-A678-5969B7D3A92FQ55234421-A25EF981-B2E3-4843-91EF-3E4698F579B4Q57728390-13272AD5-94A7-473C-9348-DA4AC3F554B5
P2860
Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 06 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@en
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@nl
type
label
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@en
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@nl
prefLabel
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@en
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@nl
P2093
P2860
P1433
P1476
Using lidocaine and benzocaine ...... antiarrhythmic drug affinity.
@en
P2093
Dorothy A Hanck
Elena Nikitina
Gregory M Lipkind
Harry A Fozzard
Megan M McNulty
Michael F Sheets
P2860
P304
P356
10.1161/CIRCRESAHA.109.198572
P577
2009-08-06T00:00:00Z