Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax. - Wikidata - wikimedia - TriplyDB

Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax.

Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax.

http://www.wikidata.org/entity/Q37328134

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Dinosaurs and ancient civilizations: reflections on the treatment of cancer Therapeutic Implications of Targeting AKT Signaling in Melanoma Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress.The interconnectedness of cancer cell signaling.Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process Phase I dose finding studies of obatoclax (GX15-070), a small molecule pan-BCL-2 family antagonist, in patients with advanced solid tumors or lymphoma.Chronic inhibition of cGMP-specific phosphodiesterase 5 suppresses endoplasmic reticulum stress in heart failure.The War on Cancer rages on.Harnessing the cell death pathway for targeted cancer treatment.Obatoclax mesylate : pharmacology and potential for therapy of hematological neoplasms.Emerging targets for combination therapy in melanomas.Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines.Noxa and cancer therapy: Tuning up the mitochondrial death machinery in response to chemotherapy.A novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.Mcl-1 and YY1 inhibition and induction of DR5 by the BH3-mimetic Obatoclax (GX15-070) contribute in the sensitization of B-NHL cells to TRAIL apoptosis.GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy.Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment Targeting GRP78 to enhance melanoma cell death.Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.Anti-cancer drug discovery and development: Bcl-2 family small molecule inhibitors.Thai Water Lily Extract Induces B16 Melanoma Cell Apoptosis and Inhibits Cellular Invasion Through the Role of Cellular Oxidants Targeting the intrinsic apoptosis pathway as a strategy for melanoma therapy.

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Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax.

http://www.wikidata.org/entity/Q37328134

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on September 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

@en

Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

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type

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Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

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Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

@nl

prefLabel

Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

@en

Human melanoma cells under end ...... by the BH3 mimetic obatoclax.

@nl

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Human melanoma cells under end ...... d by the BH3 mimetic obatoclax

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Chen Chen Jiang

http://www.w3.org/2001/XMLSchema#string

David Wroblewski

http://www.w3.org/2001/XMLSchema#string

Fan Yang

http://www.w3.org/2001/XMLSchema#string

Peter Hersey

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P2860

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

Endoplasmic reticulum stress: cell life and death decisions.

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

Structural insights into the degradation of Mcl-1 induced by BH3 domains

BH-3-only BIK functions at the endoplasmic reticulum to stimulate cytochrome c release from mitochondria

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945-955

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scholarly article

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10.1593/NEO.09692

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9

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11

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2009-09-01T00:00:00Z

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26784053

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19724688

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apoptotic process

endoplasmic reticulum

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2735806

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