Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
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Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infectionAxon regeneration impediment: the role of paired immunoglobulin-like receptor BPneumococcal Polysaccharide Vaccination Elicits IgG Anti-A/B Blood Group Antibodies in Healthy Individuals and Patients with Type I Diabetes MellitusMolecular underpinning of B-cell anergy.Local renal autoantibody production in lupus nephritisTLR2, TLR4 and the MyD88 signaling are crucial for the in vivo generation and the longevity of long-lived antibody-secreting cells.Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.Roles of B Cell-Intrinsic TLR Signals in Systemic Lupus Erythematosus.Tyrosine kinase Btk is required for NK cell activationEngagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.CD19 controls Toll-like receptor 9 responses in human B cellsIkaros Is a Negative Regulator of B1 Cell Development and Function.CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.Autoantibodies in primary biliary cirrhosis: recent progress in research on the pathogenetic and clinical significanceRole of PIR-B in autoimmune glomerulonephritis.Autoimmunity in X-linked agammaglobulinemia: Kawasaki disease and review of the literature.Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765).Signaling mechanisms regulating B-lymphocyte activation and tolerance.Ibrutinib-A double-edge sword in cancer and autoimmune disorders.TLR-induced activation of Btk -- role for endosomal MHC class II molecules revealedRegulation of immune and neural function via leukocyte Ig-like receptors.Bruton's tyrosine kinase: from X-linked agammaglobulinemia toward targeted therapy for B-cell malignancies.Multiple regulatory mechanisms control B-1 B cell activation.The Role of the Transcription Factor Ets1 in Lupus and Other Autoimmune Diseases.Bruton's Tyrosine Kinase, a Component of B Cell Signaling Pathways, Has Multiple Roles in the Pathogenesis of Lupus.Negative regulation of B cell responses and self-tolerance to RNA-related lupus self-antigen.Human CD43+ B cells are closely related not only to memory B cells phenotypically but also to plasmablasts developmentally in healthy individuals.Constitutive activation of Bruton's tyrosine kinase induces the formation of autoreactive IgM plasma cells.
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P2860
Augmented TLR9-induced Btk activation in PIR-B-deficient B-1 cells provokes excessive autoantibody production and autoimmunity.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 17 August 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@en
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@nl
type
label
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@en
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@nl
prefLabel
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@en
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@nl
P2093
P2860
P356
P1476
Augmented TLR9-induced Btk act ...... y production and autoimmunity.
@en
P2093
Akira Nakamura
Masahiro Abe
Shizuo Akira
Tomohiro Kubo
Toshiyuki Takai
Yuki Uchida
Yuko Watanabe
P2860
P304
P356
10.1084/JEM.20082392
P407
P577
2009-08-17T00:00:00Z