Highly conserved histidine plays a dual catalytic role in protein splicing: a pKa shift mechanism
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p K a Coupling at the Intein Active Site: Implications for the Coordination Mechanism of Protein Splicing with a Conserved AspartateStructural and Mutational Studies of a Hyperthermophilic Intein from DNA Polymerase II of Pyrococcus abyssiA conserved threonine spring-loads precursor for intein splicingConserved residues that modulate protein trans-splicing of Npu DnaE split inteinDesign of a Split Intein with Exceptional Protein Splicing ActivitySpontaneous proton transfer to a conserved intein residue determines on-pathway protein splicing.A mechanistic study of the spontaneous hydrolysis of glycylserine as the simplest model for protein self-cleavage.Protein splicing: how inteins escape from precursor proteins.Backbone dynamics and global effects of an activating mutation in minimized Mtu RecA inteins.Recent progress in intein research: from mechanism to directed evolution and applications.Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria.Dynamics differentiate between active and inactive inteins.Electronic structure of neighboring extein residue modulates intein C-terminal cleavage activity1H, 13C, and 15N NMR assignments of the Pyrococcus abyssi DNA polymerase II intein.SufB intein of Mycobacterium tuberculosis as a sensor for oxidative and nitrosative stresses.Mutual synergistic protein folding in split intein.¹H, ¹³C and ¹⁵N NMR assignments of a Drosophila Hedgehog autoprocessing domainExploring chemoselective S-to-N acyl transfer reactions in synthesis and chemical biology.Self-cleavage of the Pseudomonas aeruginosa Cell-surface Signaling Anti-sigma Factor FoxR Occurs through an N-O Acyl RearrangementIntrinsic energy landscapes of amino acid side-chains.Chemical bypass of intein-catalyzed N-S acyl shift in protein splicing.Intein lacking conserved C-terminal motif G retains controllable N-cleavage activity.Mechanism of C-terminal intein cleavage in protein splicing from QM/MM molecular dynamics simulations.Spontaneous C-cleavage of a mini-intein without its conserved N-terminal motif A.
P2860
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P2860
Highly conserved histidine plays a dual catalytic role in protein splicing: a pKa shift mechanism
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Highly conserved histidine pla ...... plicing: a pKa shift mechanism
@en
Highly conserved histidine pla ...... licing: a pKa shift mechanism.
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type
label
Highly conserved histidine pla ...... plicing: a pKa shift mechanism
@en
Highly conserved histidine pla ...... licing: a pKa shift mechanism.
@nl
prefLabel
Highly conserved histidine pla ...... plicing: a pKa shift mechanism
@en
Highly conserved histidine pla ...... licing: a pKa shift mechanism.
@nl
P2093
P2860
P356
P1476
Highly conserved histidine pla ...... plicing: a pKa shift mechanism
@en
P2093
Brian Pereira
Chunyu Wang
Georges Belfort
Philip T Shemella
Saroj K Nayak
Scott A McCallum
Yangzhong Liu
Zhenming Du
P2860
P304
11581-11589
P356
10.1021/JA904318W
P407
P577
2009-08-01T00:00:00Z