Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967
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The role of late I Na in development of cardiac arrhythmiasRegulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatmentLate Sodium Current in Human Atrial Cardiomyocytes from Patients in Sinus Rhythm and Atrial FibrillationUnexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current.Icariin, a Novel Blocker of Sodium and Calcium Channels, Eliminates Early and Delayed Afterdepolarizations, As Well As Triggered Activity, in Rabbit CardiomyocytesA computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current.Antiepileptic activity of preferential inhibitors of persistent sodium currentRational strategy to stop arrhythmias: Early afterdepolarizations and L-type Ca2+ current.Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts.New antiarrhythmic targets to control intracellular calcium handling.Cardiac sodium channels and inherited electrophysiological disorders: an update on the pharmacotherapy.The late sodium current in heart failure: pathophysiology and clinical relevance.Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy.The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine.Andrographolide inhibits arrhythmias and is cardioprotective in rabbits.Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytesThe Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model.Use-Dependent Block of Human Cardiac Sodium Channels by GS967.Ca2+ leak-What is it? Why should we care? Can it be managed?Anti-arrhythmic potential of the late sodium current inhibitor GS-458967 in murine Scn5a-1798insD+/- and human SCN5A-1795insD+/- iPSC-derived cardiomyocytes.Selective late sodium current inhibitor GS-458967 suppresses Torsades de Pointes by mostly affecting perpetuation but not initiation of the arrhythmia.Late sodium current inhibitors to treat exercise-induced obstruction in hypertrophic cardiomyopathy: an in vitro study in human myocardium.The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathyAltered Ca and Na Homeostasis in Human Hypertrophic Cardiomyopathy: Implications for Arrhythmogenesis
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P2860
Antiarrhythmic effects of the highly selective late sodium channel current blocker GS-458967
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 March 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Antiarrhythmic effects of the ...... nnel current blocker GS-458967
@en
Antiarrhythmic effects of the ...... nel current blocker GS-458967.
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type
label
Antiarrhythmic effects of the ...... nnel current blocker GS-458967
@en
Antiarrhythmic effects of the ...... nel current blocker GS-458967.
@nl
prefLabel
Antiarrhythmic effects of the ...... nnel current blocker GS-458967
@en
Antiarrhythmic effects of the ...... nel current blocker GS-458967.
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P2860
P1433
P1476
Antiarrhythmic effects of the ...... nnel current blocker GS-458967
@en
P2093
Luiz Belardinelli
Serge Sicouri
P2860
P304
P356
10.1016/J.HRTHM.2013.03.023
P577
2013-03-22T00:00:00Z