A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.
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PHD2: from hypoxia regulation to disease progressionThe role of PHD2 mutations in the pathogenesis of erythrocytosis.Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensingHuman high-altitude adaptation: forward genetics meets the HIF pathway.Mimicking hypoxia to treat anemia: HIF-stabilizer BAY 85-3934 (Molidustat) stimulates erythropoietin production without hypertensive effects.Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases.Identification of Small-Molecule PHD2 Zinc Finger Inhibitors that Activate Hypoxia Inducible Factor.The Zinc Finger of Prolyl Hydroxylase Domain Protein 2 Is Essential for Efficient Hydroxylation of Hypoxia-Inducible Factor α.Notch Downregulation and Extramedullary Erythrocytosis in Hypoxia-Inducible Factor Prolyl 4-Hydroxylase 2-Deficient Mice.Genetic modification of hypoxia signaling in animal models and its effect on cancer.Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathwayCongenital erythrocytosis.Prolyl hydroxylase domain enzymes: important regulators of cancer metabolism.Oxygen-dependent Regulation of Erythropoietin Receptor Turnover and Signaling.Conditional disruption of the prolyl hydroxylase domain-containing protein 2 (Phd2) gene defines its key role in skeletal development.Hypoxia-Inducible Factor and Its Role in the Management of Anemia in Chronic Kidney Disease.VHL and Hypoxia Signaling: Beyond HIF in Cancer.PHD2 inactivation in Type I cells drives HIF-2α-dependent multilineage hyperplasia and the formation of paraganglioma-like carotid bodies
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A knock-in mouse model of human PHD2 gene-associated erythrocytosis establishes a haploinsufficiency mechanism.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 11 October 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@en
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@nl
type
label
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@en
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@nl
prefLabel
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@en
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@nl
P2093
P2860
P356
P1476
A knock-in mouse model of huma ...... haploinsufficiency mechanism.
@en
P2093
Brian Keith
Heddy Kerestes
M Celeste Simon
Melanie J Percy
Patrick R Arsenault
Rebecca Lee
Tejvir S Khurana
Terence R J Lappin
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P304
33571-33584
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10.1074/JBC.M113.482364
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P50
P577
2013-10-11T00:00:00Z